{"id":"W2888894134","doi":"10.1136/bmj.k3225","title":"Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study","year":2018,"lang":"en","type":"review","venue":"BMJ","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":284,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Institutes of Health; Hjartavernd; Kulturministeriet; Novo Nordisk Fonden; Paavo Nurmen Säätiö; Medical Research Council; Servier; Tartu Ülikool; Göteborgs Läkaresällskap; Eesti Teadusagentuur; Syddansk Universitet; Sydäntutkimussäätiö; Emil Aaltosen Säätiö; Horizon 2020 Framework Programme; Vetenskapsrådet; National Institute for Health and Care Research; Javna Agencija za Raziskovalno Dejavnost RS; Centre for Medical Systems Biology; Novo Nordisk; Juho Vainion Säätiö; U.S. Department of Health and Human Services; Signe ja Ane Gyllenbergin Säätiö; Versus Arthritis; Kempe Foundation; Healthway; Ministry of Agriculture, Forestry and Fisheries; National Institute on Aging; University of Hong Kong; Svenska Läkaresällskapet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Tampereen Tuberkuloosisäätiö; Kela; Division of Materials Research; European Regional Development Fund; King's College London; Australian Cancer Research Foundation; Academy of Finland; Health Research Council of New Zealand; Nederlandse Zuivel Organisatie; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; Geelong Region Medical Research Foundation; National Science Foundation; Fondation Leducq; National Health and Medical Research Council; Suomen Kulttuurirahasto; Jewish General Hospital; Forskningsrådet för Arbetsliv och Socialvetenskap; Wellcome Trust; Wageningen University and Research; Cancer Research UK; Amgen; Steirische Wirtschaftsförderungsgesellschaft; World Anti-Doping Agency; Austrian Federal Ministry of Economy, Family and Youth; Yrjö Jahnssonin Säätiö; Chinese University of Hong Kong; Eli Lilly and Company; Foundation for Cardiovascular Research; Umeå Universitet; European Commission; Sanofi; Pfizer; National Center for Research Resources; Diabetesliitto; National and Kapodistrian University of Athens; Bundesministerium für Verkehr, Innovation und Technologie; Ministerie van Economische Zaken, Landbouw en Innovatie; ZonMw","keywords":"Genome-wide association study; Mendelian inheritance; Genetic association; Association (psychology); Medicine; Bioinformatics; Genetics; Biology; Genotype; Single-nucleotide polymorphism; Psychology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04079184,0.002078027,0.003765507,0.001560935,0.0008504522,0.001413741,0.002316249,0.002424926,0.003046629],"category_scores_gemma":[0.07798444,0.001328961,0.006208155,0.003279548,0.00109629,0.001196776,0.001083669,0.001506931,0.0004800062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007543625,"about_ca_system_score_gemma":0.0013792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003084758,"about_ca_topic_score_gemma":0.001875298,"domain_scores_codex":[0.9512479,0.03644141,0.002823509,0.005730106,0.002976564,0.0007805897],"domain_scores_gemma":[0.9781117,0.01170289,0.003132144,0.005849852,0.0009109454,0.0002924142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"systematic_review","study_design_scores_codex":[0.06105068,0.0007597369,0.7070821,0.00362238,0.1777312,0.00218424,0.0008271306,0.004925241,0.00449763,0.005453869,0.004569309,0.02729648],"study_design_scores_gemma":[0.0617894,0.01048407,0.6007468,0.001149296,0.2357324,0.006757282,0.0004474598,0.04218252,0.003953809,0.02420363,0.01213649,0.0004170139],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8048323,0.02353586,0.1538712,0.001955477,0.0008477201,0.006996109,0.004910175,0.0006303068,0.002420777],"genre_scores_gemma":[0.971604,0.001162553,0.02000108,0.0004178958,0.0001248913,0.004463689,0.001463471,0.00008376435,0.000678634],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.04079184,"threshold_uncertainty_score":0.2157304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08131588480272874,"score_gpt":0.4911804365167634,"score_spread":0.4098645517140346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}