{"id":"W2888894134","doi":"10.1136/bmj.k3225","title":"Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study","year":2018,"lang":"en","type":"review","venue":"BMJ","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":284,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Institutes of Health; Hjartavernd; Kulturministeriet; Novo Nordisk Fonden; Paavo Nurmen Säätiö; Medical Research Council; Servier; Tartu Ülikool; Göteborgs Läkaresällskap; Eesti Teadusagentuur; Syddansk Universitet; Sydäntutkimussäätiö; Emil Aaltosen Säätiö; Horizon 2020 Framework Programme; Vetenskapsrådet; National Institute for Health and Care Research; Javna Agencija za Raziskovalno Dejavnost RS; Centre for Medical Systems Biology; Novo Nordisk; Juho Vainion Säätiö; U.S. Department of Health and Human Services; Signe ja Ane Gyllenbergin Säätiö; Versus Arthritis; Kempe Foundation; Healthway; Ministry of Agriculture, Forestry and Fisheries; National Institute on Aging; University of Hong Kong; Svenska Läkaresällskapet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Tampereen Tuberkuloosisäätiö; Kela; Division of Materials Research; European Regional Development Fund; King's College London; Australian Cancer Research Foundation; Academy of Finland; Health Research Council of New Zealand; Nederlandse Zuivel Organisatie; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; Geelong Region Medical Research Foundation; National Science Foundation; Fondation Leducq; National Health and Medical Research Council; Suomen Kulttuurirahasto; Jewish General Hospital; Forskningsrådet för Arbetsliv och Socialvetenskap; Wellcome Trust; Wageningen University and Research; Cancer Research UK; Amgen; Steirische Wirtschaftsförderungsgesellschaft; World Anti-Doping Agency; Austrian Federal Ministry of Economy, Family and Youth; Yrjö Jahnssonin Säätiö; Chinese University of Hong Kong; Eli Lilly and Company; Foundation for Cardiovascular Research; Umeå Universitet; European Commission; Sanofi; Pfizer; National Center for Research Resources; Diabetesliitto; National and Kapodistrian University of Athens; Bundesministerium für Verkehr, Innovation und Technologie; Ministerie van Economische Zaken, Landbouw en Innovatie; ZonMw","keywords":"Genome-wide association study; Mendelian inheritance; Genetic association; Association (psychology); Medicine; Bioinformatics; Genetics; Biology; Genotype; Single-nucleotide polymorphism; Psychology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004119037,0.0001507458,0.001469109,0.00008076544,0.00006696589,0.000008803038,0.00008166253,0.0003003978,0.00001791717],"category_scores_gemma":[0.002217257,0.00008531244,0.0001772877,0.0001230271,0.00007763847,0.00001685799,0.00008673149,0.0004315862,0.000001316018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001049019,"about_ca_system_score_gemma":0.0007088116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001183512,"about_ca_topic_score_gemma":0.000130113,"domain_scores_codex":[0.9966322,0.00115657,0.001272804,0.0002580792,0.0005154828,0.0001648817],"domain_scores_gemma":[0.9965916,0.001242303,0.001490471,0.0003651515,0.0001908172,0.0001196502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005444392,0.0001508975,0.8130974,0.005130166,0.0001541434,0.000001539837,0.00006470971,3.176156e-8,1.425495e-7,5.662107e-8,0.0003554664,0.1809911],"study_design_scores_gemma":[0.003049094,0.0006893391,0.9219798,0.001884567,0.00139384,0.000007507723,0.00003850935,0.00002360131,2.639663e-7,0.000004158697,0.07086499,0.00006435497],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2219536,0.7715027,0.000006097548,0.0001734368,0.0001459565,0.006089135,0.00003958061,0.000004388345,0.00008506899],"genre_scores_gemma":[0.03589755,0.9633543,0.0002296592,0.00006456848,0.0002025061,0.0000739114,0.000009499265,0.00001766337,0.0001503774],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1918516,"threshold_uncertainty_score":0.347894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08131588480272874,"score_gpt":0.4911804365167634,"score_spread":0.4098645517140346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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