{"id":"W2888900018","doi":"10.1007/978-1-4939-8651-4_28","title":"Systemic and ICV Injections of Antisense Oligos into SMA Mice and Evaluation","year":2018,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Canadian Institutes of Health Research; Ministry of Education, India; Ministry of Earth Sciences","keywords":"SMA*; Chemistry; Pharmacology; Biology; Computer science; Algorithm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001339768,0.00007703758,0.0002243132,0.0002108987,0.00003085965,0.000003154192,0.00003706659,0.0001110492,0.00001387389],"category_scores_gemma":[0.0006714094,0.00006818593,0.00002750947,0.0002117588,0.0003544521,0.00000769149,0.00006858654,0.0001011266,0.000001133381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001618968,"about_ca_system_score_gemma":0.00006598891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000128631,"about_ca_topic_score_gemma":0.00002039876,"domain_scores_codex":[0.9981981,0.001140285,0.0001919772,0.0002474969,0.00008488874,0.0001372792],"domain_scores_gemma":[0.9994674,0.0001017274,0.00004225175,0.000183377,0.0001543233,0.00005090145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003941898,0.00002483092,0.009900489,0.0000776471,0.00003072977,0.00000513042,0.0002373104,7.428861e-7,0.9156188,0.0003075077,0.000003968162,0.07375339],"study_design_scores_gemma":[0.002917258,0.001535175,0.02235804,0.0001414269,0.0001990823,0.0007321591,0.0005232726,0.004795318,0.9594973,0.006385016,0.0007337908,0.0001821536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8098405,0.003668274,0.1855235,0.0001407107,0.00006002281,0.0004184525,9.066628e-7,0.000005901237,0.0003417462],"genre_scores_gemma":[0.7692055,0.0003450969,0.2302638,0.0001077631,0.00001886926,0.00002714785,0.000003881988,0.000009759638,0.00001827231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07357123,"threshold_uncertainty_score":0.2780541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03997114412849086,"score_gpt":0.4808754055578225,"score_spread":0.4409042614293316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}