{"id":"W2888927593","doi":"10.1016/j.omto.2018.08.003","title":"APOBEC3 Mediates Resistance to Oncolytic Viral Therapy","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oncolytics Biotech; National Institute for Health and Care Research; National Cancer Institute; Cancer Research UK; Rosetrees Trust; Richard M. Schulze Family Foundation; Mayo Foundation for Medical Education and Research; University of Minnesota; Mayo Clinic","keywords":"Oncolytic virus; Vesicular stomatitis virus; Biology; Virotherapy; Gene knockdown; Virology; Virus; Cancer cell; Interferon; Cancer research; Cell culture; Cancer; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277588,0.0001768734,0.0001548762,0.0001202081,0.0001847363,0.0003784123,0.0001499279,0.0005161195,0.00155187],"category_scores_gemma":[0.0001767448,0.00008524759,0.0001720717,0.00008648266,0.0002044541,0.0001732568,0.0002164997,0.0008189919,0.000424246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006309649,"about_ca_system_score_gemma":0.0002576962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002741623,"about_ca_topic_score_gemma":0.002122398,"domain_scores_codex":[0.9998795,0.00001818026,0.000006264557,0.00002176565,0.00003716542,0.00003701854],"domain_scores_gemma":[0.9999181,0.00001698058,0.0000212167,0.00001013715,0.00001579193,0.00001781349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001053305,0.00002391258,0.0008098665,0.00005107079,0.000007926412,0.00017958,0.00002982031,0.0001181733,0.9933066,0.0004683705,0.0003028996,0.004596449],"study_design_scores_gemma":[0.00005549722,0.0005005723,0.02269449,0.00003547929,0.00003642899,0.002665123,0.0001031127,0.005429434,0.9405817,0.0009472677,0.0269286,0.00002219481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967986,0.01369142,0.005640765,0.0007530331,0.00008427975,0.00007268466,0.0003384314,0.0003144078,0.01111905],"genre_scores_gemma":[0.9956528,0.001052562,0.0004457048,0.00009650555,0.000009667914,0.00001205452,0.0001193903,0.00001108563,0.002600245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002741623,"threshold_uncertainty_score":0.005451381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205703581799672,"score_gpt":0.3219701523271543,"score_spread":0.3013997941471871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}