{"id":"W2888927593","doi":"10.1016/j.omto.2018.08.003","title":"APOBEC3 Mediates Resistance to Oncolytic Viral Therapy","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oncolytics Biotech; National Institute for Health and Care Research; National Cancer Institute; Cancer Research UK; Rosetrees Trust; Richard M. Schulze Family Foundation; Mayo Foundation for Medical Education and Research; University of Minnesota; Mayo Clinic","keywords":"Oncolytic virus; Vesicular stomatitis virus; Biology; Virotherapy; Gene knockdown; Virology; Virus; Cancer cell; Interferon; Cancer research; Cell culture; Cancer; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007534863,0.0005298629,0.000421387,0.0001954789,0.0002769008,0.0001289818,0.001067214,0.0003473927,0.0002237677],"category_scores_gemma":[0.000140454,0.0005034814,0.0002696982,0.0005567357,0.0003762183,0.00001080865,0.0001917189,0.0002674627,0.0004275115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001416516,"about_ca_system_score_gemma":0.0004898288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001624665,"about_ca_topic_score_gemma":0.0002947355,"domain_scores_codex":[0.9964359,0.0003205915,0.0004904727,0.0009780129,0.0007952449,0.000979713],"domain_scores_gemma":[0.997361,0.00004322254,0.0001407067,0.001523353,0.0004831484,0.0004485878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006568765,0.0002711995,0.0001580846,0.000008447995,0.0002210382,0.00003487551,0.0002529909,0.00004788092,0.9652041,0.0001105042,0.006525428,0.02059669],"study_design_scores_gemma":[0.002137409,0.007932242,0.0001463769,0.00002046541,0.000008096346,0.000005980916,0.00003495222,0.0000418707,0.7442215,0.0004069957,0.2445453,0.0004988066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852782,0.004722773,0.002299209,0.001567142,0.0003784026,0.001220912,0.0000364052,0.00008848257,0.004408421],"genre_scores_gemma":[0.979514,0.002036559,0.002543203,0.009587049,0.001281598,0.0002103393,0.00008379444,0.0002170357,0.004526433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2380199,"threshold_uncertainty_score":0.9997417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205703581799672,"score_gpt":0.3219701523271543,"score_spread":0.3013997941471871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}