{"id":"W2888936236","doi":"10.1016/j.taap.2018.08.021","title":"Integration of sperm DNA damage assessment into OECD test guidelines for genotoxicity testing using the MutaMouse model","year":2018,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Environment and Climate Change Canada; Health Canada","funders":"Health Canada","keywords":"Genotoxicity; Sperm; Micronucleus test; DNA damage; Terminal deoxynucleotidyl transferase; TUNEL assay; DNA fragmentation; Comet assay; Andrology; Somatic cell; Biology; Molecular biology; Germ cell; Apoptosis; Toxicology; DNA; Chemistry; Genetics; Toxicity; Programmed cell death; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004089287,0.001040993,0.0006979133,0.002583625,0.0004353854,0.00114219,0.001871755,0.0009875825,0.002250647],"category_scores_gemma":[0.002618378,0.0003720272,0.0008652775,0.0009378166,0.0006744115,0.0008575526,0.001673148,0.001140085,0.0007899921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001294346,"about_ca_system_score_gemma":0.00204604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00561908,"about_ca_topic_score_gemma":0.01405696,"domain_scores_codex":[0.99597,0.0007247587,0.0002582457,0.0002944268,0.002622174,0.0001304663],"domain_scores_gemma":[0.9973574,0.0004094198,0.0003554978,0.0004569425,0.001314268,0.0001063982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001775194,0.0002526215,0.006429016,0.0005932166,0.0001267305,0.0001582689,0.0001137876,0.00532501,0.9365577,0.004166274,0.001115816,0.04498412],"study_design_scores_gemma":[0.0000246576,0.001935272,0.009335262,0.0001203175,0.0002400687,0.0004405834,0.0001719013,0.01086397,0.9480537,0.002888875,0.02583932,0.0000862467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3635316,0.006960397,0.5625184,0.001521536,0.0003856463,0.002151578,0.007872224,0.003037244,0.05202144],"genre_scores_gemma":[0.7406835,0.007385958,0.2197779,0.0008358364,0.00003366779,0.001034965,0.007424139,0.0003216112,0.02250242],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00561908,"threshold_uncertainty_score":0.02162647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0900647593369651,"score_gpt":0.4042891803294894,"score_spread":0.3142244209925243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}