{"id":"W2888994582","doi":"10.1007/s40265-018-0971-x","title":"Beyond the TNF-α Inhibitors: New and Emerging Targeted Therapies for Patients with Axial Spondyloarthritis and their Relation to Pathophysiology","year":2018,"lang":"en","type":"review","venue":"Drugs","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Immunology; Medicine; Innate immune system; Unfolded protein response; Tumor necrosis factor alpha; Inflammation; Immune system; Endoplasmic reticulum; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001020596,0.000419893,0.001048774,0.0001120613,0.0003120582,0.00003236728,0.0000591592,0.0001661496,0.00001612346],"category_scores_gemma":[0.00005439186,0.0002187982,0.0001475906,0.0001828442,0.0001459255,0.0000602872,0.00008841386,0.0001490185,0.000009776399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004186779,"about_ca_system_score_gemma":0.00007735197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000302836,"about_ca_topic_score_gemma":0.00001961637,"domain_scores_codex":[0.9986801,0.00006676022,0.0003343992,0.0004847107,0.0001331748,0.0003009293],"domain_scores_gemma":[0.9990996,0.0002064359,0.0001902325,0.0002627495,0.0001097889,0.0001312364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001884463,0.00005194075,0.0001645225,0.0006148204,0.0003623637,0.000003166529,0.002375629,1.197771e-8,0.000001020691,0.00005914636,0.002619569,0.9935594],"study_design_scores_gemma":[0.00332844,0.002020252,0.001419062,0.003981476,0.000547698,0.00001545392,0.0002790669,6.123472e-7,0.000001739213,0.0006048485,0.9875108,0.0002905524],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02627289,0.9699498,0.00001101296,0.0003795197,0.000344835,0.002676265,0.0002364443,0.00003259426,0.00009660572],"genre_scores_gemma":[0.002725407,0.9944959,0.0004753424,0.0002769025,0.0008346738,0.0003245951,0.000555652,0.00007738852,0.0002341135],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9932688,"threshold_uncertainty_score":0.8922332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083069909199197,"score_gpt":0.2610095401965357,"score_spread":0.2501788411045437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}