{"id":"W2889011303","doi":"10.1080/19336950.2018.1502585","title":"Cystic fibrosis transmembrane conductance regulator (CFTR): Making an ion channel out of an active transporter structure","year":2018,"lang":"en","type":"review","venue":"Channels","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette transporter; Cystic fibrosis; Transmembrane protein; Cytoplasm; Chemistry; Ion channel; Cell biology; Ion transporter; Transporter; Biophysics; Membrane potential; Membrane protein; Transmembrane domain; Regulator; Biochemistry; Membrane; Biology; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003577705,0.0009951693,0.003641301,0.0005475894,0.0001418796,0.00005180804,0.0006772101,0.0008078215,0.0005971524],"category_scores_gemma":[0.0001703148,0.0007846735,0.0007054338,0.0006071393,0.0005976028,0.0006160616,0.00004208488,0.0008782824,0.00002568229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605018,"about_ca_system_score_gemma":0.0005812082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001439684,"about_ca_topic_score_gemma":0.00005819678,"domain_scores_codex":[0.9950796,0.0003225068,0.001234924,0.001390424,0.001031221,0.000941263],"domain_scores_gemma":[0.9966541,0.0002210485,0.000710574,0.001387545,0.0004564096,0.0005703045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002384499,0.0006370267,7.866318e-7,0.1568436,0.001241664,0.0002722883,0.006034013,0.00002903111,0.02031804,0.00004924606,0.0002657255,0.811924],"study_design_scores_gemma":[0.005982865,0.01067659,0.0001616865,0.2161745,0.007684624,0.001169861,0.001141594,0.000915569,0.03783477,0.00196406,0.7122858,0.004008052],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006060587,0.9847825,0.0007017875,0.00003972934,0.001388653,0.003486122,0.00326598,0.0001648809,0.0001098101],"genre_scores_gemma":[0.05097942,0.9350985,0.00441067,0.00007613227,0.004094565,0.0003220526,0.003902306,0.0005283652,0.0005879691],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.807916,"threshold_uncertainty_score":0.9994604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06710270976420464,"score_gpt":0.3787694109179339,"score_spread":0.3116667011537292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}