{"id":"W2889011303","doi":"10.1080/19336950.2018.1502585","title":"Cystic fibrosis transmembrane conductance regulator (CFTR): Making an ion channel out of an active transporter structure","year":2018,"lang":"en","type":"review","venue":"Channels","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette transporter; Cystic fibrosis; Transmembrane protein; Cytoplasm; Chemistry; Ion channel; Cell biology; Ion transporter; Transporter; Biophysics; Membrane potential; Membrane protein; Transmembrane domain; Regulator; Biochemistry; Membrane; Biology; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003405313,0.0005731562,0.0007343647,0.002010176,0.0003374152,0.0008979778,0.0006281048,0.0009835823,0.003884528],"category_scores_gemma":[0.0004835837,0.0001464691,0.0003443156,0.001648569,0.0006176776,0.001248991,0.0006880783,0.001302307,0.003487865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004656106,"about_ca_system_score_gemma":0.0009569005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006442005,"about_ca_topic_score_gemma":0.001006385,"domain_scores_codex":[0.9998506,0.00002240759,0.00001949868,0.00002579423,0.00006432609,0.00001721739],"domain_scores_gemma":[0.999844,0.00005729416,0.00002506267,0.000006297759,0.00004556885,0.00002183471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003687441,0.00004924968,0.0001871277,0.01038507,0.00004585232,0.0003634681,0.0001155985,0.000185636,0.003548473,0.01044234,0.04456595,0.9300744],"study_design_scores_gemma":[0.000004215123,0.00002842714,0.0002157406,0.001064668,0.00002677795,0.00137689,0.0000386189,0.00002714646,0.0003789917,0.001515733,0.9953164,0.000006528958],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002567545,0.9947439,0.0003428351,0.0007381449,0.0005024001,0.00000943746,0.00003292866,0.00002204839,0.003351414],"genre_scores_gemma":[0.001393917,0.9959608,0.0003516018,0.000255694,0.0002508752,0.000007804038,0.00005286219,0.000002822982,0.001723691],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003884528,"threshold_uncertainty_score":0.012995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06710270976420464,"score_gpt":0.3787694109179339,"score_spread":0.3116667011537292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}