{"id":"W2889012164","doi":"10.1101/405415","title":"Clonotypic Heterogeneity In Cutaneous T-Cell Lymphoma Revealed By Comprehensive Whole Exome/Transcriptome Sequencing","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cutaneous lymphoproliferative disorders research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Bispebjerg Hospital; University of Alberta; Canadian Dermatology Foundation","keywords":"T-cell receptor; Mycosis fungoides; Biology; Transcriptome; Lymphoma; Repertoire; Exome sequencing; Gene rearrangement; T cell; Exome; Peripheral T-cell lymphoma; Immunology; Gene; Genetics; Mutation; Immune system; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0006734595,0.001277431,0.001890115,0.0008838889,0.0002659936,0.0002591608,0.0008854078,0.001264093,0.0001400727],"category_scores_gemma":[0.0003600719,0.001420853,0.0004392483,0.001112829,0.0005809313,0.0001574313,0.0006589628,0.001344017,0.0004382269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003360295,"about_ca_system_score_gemma":0.002842066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004727237,"about_ca_topic_score_gemma":0.00004088912,"domain_scores_codex":[0.9927942,0.0006263425,0.001305334,0.002363598,0.001245311,0.001665276],"domain_scores_gemma":[0.9945492,0.0001944916,0.0004899528,0.002393115,0.001543733,0.0008295753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006409796,0.0008347172,0.04751083,0.001929548,0.0002803256,0.002250217,0.00007144603,0.00003729045,0.9446642,0.000007693327,0.001766893,0.000005802685],"study_design_scores_gemma":[0.01051288,0.001102811,0.05079318,0.002864949,0.0004780176,0.00001627433,0.00007262018,0.003550204,0.912205,0.00000834451,0.01504844,0.003347317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890266,0.0053296,0.0003475889,0.000350926,0.0007111194,0.002962119,0.0007441763,0.0004619936,0.00006585807],"genre_scores_gemma":[0.9951677,0.0008116903,0.001834711,0.00089418,0.0004188765,0.0004067543,0.000008768437,0.0003798617,0.00007745618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03245929,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473748676430964,"score_gpt":0.2659109141328974,"score_spread":0.2411734273685878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}