{"id":"W2889037229","doi":"10.2337/db18-0410","title":"The Dipeptidyl Peptidase 4 Substrate CXCL12 Has Opposing Cardiac Effects in Young Mice and Aged Diabetic Mice Mediated by Ca2+ Flux and Phosphoinositide 3-Kinase γ","year":2018,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Boehringer Ingelheim","keywords":"Phospholamban; Internal medicine; Endocrinology; Dipeptidyl peptidase-4; Dipeptidyl peptidase; Contractility; Population; Diabetes mellitus; Dipeptidyl peptidase-4 inhibitor; Phosphoinositide 3-kinase; Glucagon-like peptide-1; Protein kinase A; Medicine; Type 2 diabetes; Phosphorylation; Chemistry; Heart failure; Biology; Protein kinase B; Cell biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003387964,0.0008323693,0.0006195221,0.0007659657,0.0002499462,0.0005039109,0.000352933,0.0005774884,0.00227314],"category_scores_gemma":[0.000150536,0.0004541938,0.0006558466,0.000261152,0.0005787792,0.0004711497,0.0003068363,0.001464464,0.000347662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004137559,"about_ca_system_score_gemma":0.0003233243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008304881,"about_ca_topic_score_gemma":0.001533261,"domain_scores_codex":[0.9996843,0.00003750579,0.00004157253,0.00008277649,0.00005064916,0.0001031502],"domain_scores_gemma":[0.9993457,0.00002555658,0.000180325,0.00003573703,0.00003079997,0.0003817152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001227745,0.00009395392,0.0003399712,0.00007645593,0.0000144239,0.00008551135,0.00001782782,0.00002483307,0.9964814,0.0001195832,0.00009450397,0.001423745],"study_design_scores_gemma":[0.0004925011,0.00470288,0.04742557,0.00006159875,0.000180018,0.000746975,0.0001870978,0.0009349234,0.9398004,0.0002967948,0.005130497,0.00004066602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912618,0.003386867,0.001857134,0.0004226361,0.000200589,0.00003429121,0.0009377718,0.0002211297,0.001677697],"genre_scores_gemma":[0.9830298,0.003765746,0.002779392,0.0006910019,0.0001035843,0.0001937884,0.001258795,0.0001258576,0.008051999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00227314,"threshold_uncertainty_score":0.00760442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007154482609745246,"score_gpt":0.2166791799653386,"score_spread":0.2095246973555933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}