{"id":"W2889068572","doi":"10.1016/j.stem.2018.08.002","title":"Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Medical Research Council; Canadian Institutes of Health Research; Chinese Academy of Medical Sciences Initiative for Innovative Medicine; Azrieli Foundation; Israel Science Foundation; International Development Research Centre; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cancer Research UK","keywords":"Biology; Haematopoiesis; Darkness; Stem cell; Cell biology; Cellular differentiation; Immunology; Botany; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00015011,0.0003000548,0.0004557121,0.0001084258,0.0001931062,0.0001086876,0.0002183428,0.0001475027,0.00005904364],"category_scores_gemma":[0.000006495872,0.0002617449,0.00007617684,0.000163154,0.0002377783,0.0001537677,0.0001418995,0.0001639758,0.00006233891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000277636,"about_ca_system_score_gemma":0.0000450106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006341608,"about_ca_topic_score_gemma":0.000006968124,"domain_scores_codex":[0.997964,0.0001698673,0.0004525875,0.0006666134,0.0002889704,0.0004579133],"domain_scores_gemma":[0.9986872,0.0002267979,0.0003366218,0.0004438354,0.00007279324,0.0002327589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009523596,0.0001873412,0.003148437,0.0005142248,0.00000429911,0.00002472028,0.001972128,6.068302e-7,0.9918721,0.0009090345,0.000381926,0.0008899873],"study_design_scores_gemma":[0.001975933,0.0002038238,0.007653438,0.00008563794,0.00005408267,0.00003725262,0.000281378,0.0003267836,0.9872774,0.00009436405,0.00171314,0.0002967488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881073,0.001014194,0.0007955554,0.00007645475,0.0004769449,0.0004880202,0.00004902097,0.00005043358,0.008942049],"genre_scores_gemma":[0.9924141,0.0002289285,0.00002299956,0.0001254154,0.00007850948,0.00001797079,0.000002990951,0.00003976422,0.007069328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004594642,"threshold_uncertainty_score":0.9999835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102630410237136,"score_gpt":0.2045918175506856,"score_spread":0.1935655134483142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}