{"id":"W2889108584","doi":"10.1016/j.jneuroim.2018.08.015","title":"Dysfunctional RNA binding proteins and stress granules in multiple sclerosis","year":2018,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cameco (Canada); University of Saskatchewan","funders":"Saskatoon City Hospital Foundation; University of Saskatchewan","keywords":"Stress granule; Colocalization; Pathogenesis; RNA-binding protein; Multiple sclerosis; Cytoplasm; Dysfunctional family; Translation (biology); Amyotrophic lateral sclerosis; RNA; Cell biology; Biology; Medicine; Messenger RNA; Immunology; Pathology; Genetics; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941451,0.00007959663,0.0001349691,0.0001611174,0.00008111291,0.00001931711,0.0001404857,0.00008452492,0.00001242155],"category_scores_gemma":[0.0002916318,0.00006810598,0.00004385207,0.0000828486,0.0001948792,0.000009202561,0.0000925921,0.0002009816,0.000003360849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000116616,"about_ca_system_score_gemma":0.00005397482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002104652,"about_ca_topic_score_gemma":0.00006919959,"domain_scores_codex":[0.9992341,0.00009258289,0.0002323727,0.000134495,0.0001019022,0.0002045479],"domain_scores_gemma":[0.9995722,0.00002936438,0.0001226577,0.0001082221,0.0001194701,0.00004808899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003599059,0.00004905689,0.03316931,0.000005653209,0.00002602625,0.00001741782,0.00002018119,0.000005614922,0.9624567,0.00001470068,0.00009334319,0.003782098],"study_design_scores_gemma":[0.001965185,0.002457182,0.7222109,0.00007122553,0.000006879114,0.0003090042,0.0001188539,0.00009011146,0.270629,0.00005555884,0.001969841,0.0001162614],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986619,0.0005552678,0.0001561641,0.0003204361,0.0001652095,0.00007111208,0.000007055019,0.000001915957,0.00006095027],"genre_scores_gemma":[0.9987644,0.000497417,0.0003135119,0.00006014265,0.0001984859,0.000002577944,0.000003600553,0.000009865226,0.0001500101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6918277,"threshold_uncertainty_score":0.2777281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03612084349472142,"score_gpt":0.2587894474259937,"score_spread":0.2226686039312723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}