{"id":"W2889142294","doi":"10.1002/adtp.201800038","title":"Controlled Non‐Viral Gene Delivery in Cartilage and Bone Repair: Current Strategies and Future Directions","year":2018,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"European Research Council; Advanced Materials and Bioengineering Research; Science Foundation Ireland","keywords":"Gene delivery; Genetic enhancement; Regeneration (biology); Transduction (biophysics); Viral vector; Regenerative medicine; Biology; Gene; Bioinformatics; Medicine; Cell biology; Stem cell; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007213659,0.0001489725,0.0001811561,0.00004499943,0.00008437032,0.00003406253,0.00005335552,0.00009222386,0.000003968531],"category_scores_gemma":[0.000004172291,0.0001317379,0.00005554607,0.00005554265,0.0001352931,0.00001844348,0.00004911498,0.00008830375,0.000002125754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008393004,"about_ca_system_score_gemma":0.00004239943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007653924,"about_ca_topic_score_gemma":0.0002348523,"domain_scores_codex":[0.9992549,0.00003521598,0.0001799124,0.0002808081,0.00005803072,0.000191112],"domain_scores_gemma":[0.9996219,0.000009701903,0.00005125666,0.0001911945,0.00008294743,0.00004304321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006944629,0.00005833793,0.0009325344,0.00001234553,0.00005791014,0.000003792813,0.0002976901,0.000009537267,0.9186623,0.0001034965,0.00001561439,0.07915199],"study_design_scores_gemma":[0.01258395,0.003224863,0.01968935,0.00008590482,0.0002052374,0.00008209526,0.003487603,0.001182768,0.5033929,0.001568705,0.4533848,0.001111832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657665,0.03324701,0.0001648355,0.00008122659,0.0002856329,0.0001821187,0.00001047163,0.00001835877,0.0002437798],"genre_scores_gemma":[0.971471,0.02727566,0.000493375,0.0002328633,0.0003838056,0.00002519031,0.00001655189,0.00001346712,0.00008810191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4533692,"threshold_uncertainty_score":0.5372116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009670644528970328,"score_gpt":0.2698992024739791,"score_spread":0.2602285579450088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}