{"id":"W2889150696","doi":"10.1016/j.celrep.2018.07.090","title":"Rapid and Integrative Discovery of Retina Regulatory Molecules","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of General Medical Sciences; National Eye Institute; National Human Genome Research Institute; Intellectual and Developmental Disabilities Research Center; Boston Medical Center; National Institutes of Health; Cancer Prevention and Research Institute of Texas; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Robert and Janice McNair Foundation; National Institute on Aging; Brain Research Foundation","keywords":"Retina; Retinal; Biology; Neuroscience; Genetic screen; Gene; Computational biology; Mutant; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001191373,0.00009329332,0.00009888386,0.00002347517,0.00003308976,0.00001061184,0.00004028167,0.00006587096,0.00001303177],"category_scores_gemma":[0.00006424974,0.00007564135,0.00003958205,0.00003934598,0.0002306359,0.000004042758,0.0000692848,0.00002859838,0.000001057385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003182404,"about_ca_system_score_gemma":0.00005896647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006554267,"about_ca_topic_score_gemma":0.000005425746,"domain_scores_codex":[0.9993796,0.00001963406,0.00018622,0.0002351395,0.00007959719,0.00009975944],"domain_scores_gemma":[0.9995392,0.000004389873,0.0001352665,0.0002119864,0.00007666798,0.00003248698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007714174,0.00003749826,0.01659576,0.00003237231,0.00002303357,0.00002610006,0.0001886507,2.41416e-7,0.9722624,0.00009487254,0.007260405,0.003401554],"study_design_scores_gemma":[0.000104179,0.0002210779,0.01616791,0.00001956137,0.000008928983,0.00003471692,0.000197059,0.000002478206,0.9601551,0.0003007278,0.0226698,0.0001184167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9513594,0.001320433,0.0002765191,0.00002130927,0.0001036848,0.00007634747,9.82998e-7,0.00000413979,0.04683722],"genre_scores_gemma":[0.9951059,0.000289651,0.0005172875,0.00005018641,0.00005158096,0.00000379223,0.00003141841,0.000009208536,0.003940965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04374655,"threshold_uncertainty_score":0.3084565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004823788903031478,"score_gpt":0.2111448911601602,"score_spread":0.2063211022571287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}