{"id":"W2889156009","doi":"10.1021/acs.biomac.8b01066","title":"Acid Degradable Cationic Galactose-Based Hyperbranched Polymers as Nanotherapeutic Vehicles for Epidermal Growth Factor Receptor (EGFR) Knockdown in Cervical Carcinoma","year":2018,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions","keywords":"Methacrylamide; Chemistry; Epidermal growth factor receptor; Gene knockdown; Gene silencing; Small interfering RNA; Raft; Cancer research; Molecular biology; Cell biology; Transfection; Biochemistry; Biology; Receptor; Polymer; Polymerization; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001112517,0.0003114192,0.0002584952,0.0001332397,0.0001480076,0.00005837795,0.0003711446,0.0002892382,0.0001834103],"category_scores_gemma":[0.00008889283,0.0002963305,0.0001964625,0.0001951346,0.000221668,0.00001272948,0.00005896269,0.00007453089,0.00009065688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000613665,"about_ca_system_score_gemma":0.0002800316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003189611,"about_ca_topic_score_gemma":0.0002858426,"domain_scores_codex":[0.9982094,0.0001051728,0.0003580323,0.000619332,0.000160297,0.0005477589],"domain_scores_gemma":[0.9991347,0.00003664034,0.0001116382,0.0003895304,0.0001937858,0.0001337423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004986784,0.000126456,0.008374185,0.00003849104,0.00005349642,0.000003680574,0.00007836775,5.083901e-7,0.9867066,0.00005351685,0.0004655543,0.003600426],"study_design_scores_gemma":[0.001400052,0.0009547914,0.01497678,0.00002671926,0.00002070447,0.00001147457,0.00005954572,0.0001214737,0.9780803,0.00008559082,0.003878716,0.0003838336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952409,0.001664019,0.001296247,0.0007071829,0.0002383414,0.0003847186,0.0001122734,0.0000295498,0.000326728],"genre_scores_gemma":[0.9966325,0.00004710913,0.0009793051,0.001351351,0.0002807692,0.0001117736,0.0002689439,0.00005536705,0.0002729021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008626317,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695664969122344,"score_gpt":0.2606856192248111,"score_spread":0.2437289695335877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}