{"id":"W2889160320","doi":"10.1101/407593","title":"Gp78 E3 ubiquitin ligase mediates both basal and damage-induced mitophagy","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Mitophagy; Mitochondrion; Autophagy; Cell biology; PINK1; Ubiquitin ligase; Parkin; Biology; Endoplasmic reticulum; Mitochondrial fission; Autophagosome; ATG5; Ubiquitin; Biochemistry; Apoptosis; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639663,0.0003492902,0.0003825159,0.000198099,0.0002902701,0.0006763348,0.0002037645,0.0004755899,0.002220497],"category_scores_gemma":[0.0002155156,0.0001238757,0.0002770382,0.0001777812,0.0003061298,0.0004447383,0.0003792613,0.0005734352,0.001214716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004699149,"about_ca_system_score_gemma":0.0002516456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004608648,"about_ca_topic_score_gemma":0.0003428542,"domain_scores_codex":[0.9997972,0.00001680086,0.00001759024,0.00004755382,0.00006611015,0.00005471981],"domain_scores_gemma":[0.999913,0.000009837288,0.00001852505,0.00001528943,0.00001512017,0.00002825779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001884156,0.00002402381,0.0004953595,0.00007543105,0.00001132002,0.000171681,0.00002230344,0.0001008876,0.9963902,0.0006508357,0.0002657007,0.001603953],"study_design_scores_gemma":[0.00002619421,0.00004820389,0.005021589,0.000006635837,0.000008088511,0.0004877106,0.00002462608,0.001807937,0.9892798,0.0002389077,0.003045586,0.000004650638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852379,0.001624311,0.007801316,0.0003291488,0.00007108267,0.00003429384,0.0009220678,0.0002384279,0.003741608],"genre_scores_gemma":[0.9928083,0.0004520149,0.001710827,0.00005137473,0.00001242043,0.00002317421,0.001128295,0.00004076202,0.003772739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002220497,"threshold_uncertainty_score":0.007428229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01581564078322462,"score_gpt":0.2518318593171939,"score_spread":0.2360162185339693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}