{"id":"W2889171754","doi":"10.1101/399402","title":"The genetic architecture of the human cerebral cortex","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; University of Calgary; McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"FP7 Ideas: European Research Council; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; Helmholtz Zentrum München; National Health and Medical Research Council; Australian Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Horizon 2020 Framework Programme; University of California, Irvine; University of California, San Francisco; Queensland Brain Institute; University of California, San Diego; University of California, Davis; Directorate for Biological Sciences; National Institutes of Health; Max Planck Instituut voor Psycholinguïstiek; Dementia Centre for Research Collaboration; University of California, Los Angeles; Avera Institute for Human Genetics; Macquarie Group Foundation; National Institute on Aging; Universität Greifswald; Epilepsy Society; Instituut Born-Bunge; Stiftelsen Konsul Thure Carlssons Minne; Centre for Cognitive Ageing and Cognitive Epidemiology; Ramsay Health Care; Ministry of Cultural Affairs; Vlaamse regering; Alzheimer Nederland; National Healthcare Group; National Institute of Biomedical Imaging and Bioengineering; Novo Nordisk Fonden; University College London Hospitals NHS Foundation Trust; Mutuelle Générale de l'Education Nationale; Universiteit Antwerpen; Swedish Brain Power; Bergens Forskningsstiftelse; Universidade Estadual de Campinas; Université de Bordeaux; Universitetet i Oslo; National Center for PTSD, U.S. Department of Veterans Affairs; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universitair Medisch Centrum Groningen; Universitetet i Bergen; Helse Midt-Norge; National Medical Research Council; Norges Forskningsråd; Stockholms Läns Landsting; Vetenskapsrådet; Novo Nordisk; Helse Sør-Øst RHF; Max-Planck-Gesellschaft; Oesterreichische Nationalbank; Karolinska Institutet; University of Toronto; Maryland Population Research Center, University of Maryland; Ministero dell’Istruzione, dell’Università e della Ricerca; Accare; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fonds Wetenschappelijk Onderzoek; Siemens Healthineers; Innovative Medicines Initiative; Fondation pour la Recherche Médicale; Fondazione Cariplo; King Faisal Specialist Hospital and Research Centre; Radboud Universiteit; Compute Canada; Russian Foundation for Basic Research; Vrije Universiteit Amsterdam; Norges Teknisk-Naturvitenskapelige Universitet; Universiteit Utrecht; Technische Universiteit Delft; ZonMw; National Institute of Mental Health; Case Western Reserve University; USF Health Byrd Alzheimer's Institute; University of Sydney; Johns Hopkins University; Wellcome Trust; Agence Nationale de la Recherche; Murdoch University; Deutsche Forschungsgemeinschaft; University of Galway; Cardiff University; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; European Commission; Brown University; Newcastle University; NIHR Cambridge Biomedical Research Centre; Massachusetts General Hospital; University College London; Jewish General Hospital; Austrian Science Fund; University of Queensland; National Institute for Health and Care Research; Alzheimer's Research Trust; Gillings School of Public Health; Alzheimer's Society; King's College London; Lieber Institute for Brain Development; Ministero della Salute; European Federation of Pharmaceutical Industries and Associations; Institut National de la Santé et de la Recherche Médicale; Government of Ontario; Leids Universitair Medisch Centrum; Sanofi; Neuroscience Research Australia; Yale University; University of Texas Health Science Center at Houston; Pratt Foundation; Foundation for the National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; Dartmouth College; Belgian Federal Science Policy Office; Albert Einstein College of Medicine, Yeshiva University; University of South Florida; Brain and Behavior Research Foundation; McGill University; U.S. Department of Veterans Affairs; U.S. Department of Energy; Harvard T.H. Chan School of Public Health; Fondation pour la Recherche sur Alzheimer; Radboud Universitair Medisch Centrum; University of New South Wales; Medical Center, University of Rochester; University of Pittsburgh; Wake Forest University; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; York University; Fondation de l'Avenir pour la Recherche Médicale Appliquée; EU Joint Programme – Neurodegenerative Disease Research; Centre National de la Recherche Scientifique; Pfizer; University of Washington; National Heart, Lung, and Blood Institute; Ohio State University; Universiteit Leiden; Cleveland Clinic; Hospital for Sick Children; School of Medicine, Boston University; Northwestern University; Trinity College Dublin; CurePSP; Karl-Franzens-Universität Graz; Svenska Forskningsrådet Formas; MetLife Foundation; Eli Lilly and Company; Instituto de Investigación Marqués de Valdecilla; Stichting Dioraphte; Medizinische Universität Graz; Texas Tech University; Sylvia and Charles Viertel Charitable Foundation; Fondation de France; University of Pennsylvania; Virginia Commonwealth University; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Stanley Medical Research Institute; Age UK; University of Southern California; Emory University; Alzheimer's Association; Hersenstichting; U.S. Department of Defense; Brigham and Women's Hospital; U.S. Department of Health and Human Services; GlaxoSmithKline; University of Rochester; Heart and Stroke Foundation of Canada; NIHR Newcastle Biomedical Research Centre; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Fondation Leducq; National Science Foundation; Center of Excellence for Stress and Mental Health; Yeshiva University; Rush University; Georgetown University; Science Foundation Ireland; Fondazione Cassa di Risparmio di Pistoia e Pescia","keywords":"Cortex (anatomy); Human brain; Biology; Neuroscience; Genetic architecture; Cerebral cortex; Cognition; Evolutionary biology; Genetics; Gene; Quantitative trait locus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007361079,0.0003084557,0.0004162393,0.00117489,0.000299887,0.0008237832,0.0003520117,0.000400541,0.001747911],"category_scores_gemma":[0.002467571,0.0002740167,0.0005692879,0.001529656,0.0007067773,0.0002951174,0.000515331,0.0003783694,0.0002298891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003528079,"about_ca_system_score_gemma":0.0004200043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006915939,"about_ca_topic_score_gemma":0.006653067,"domain_scores_codex":[0.9994439,0.0001489904,0.00004427419,0.000223844,0.00009827812,0.00004058688],"domain_scores_gemma":[0.9991893,0.0003102932,0.0002581349,0.0001348319,0.00007172729,0.00003570559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008258336,0.00003381355,0.8874106,0.0006288612,0.004807777,0.001227074,0.0005252603,0.004208714,0.03473857,0.003510561,0.003839749,0.05824324],"study_design_scores_gemma":[0.0000223546,0.00004456883,0.9905735,0.00006601171,0.0005666977,0.0009481137,0.00009268978,0.0008004979,0.001354634,0.004213352,0.001302242,0.00001531583],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795849,0.009041113,0.003912374,0.001379962,0.00004210418,0.00001977479,0.003653828,0.0001156719,0.002250205],"genre_scores_gemma":[0.9945396,0.002307133,0.001594499,0.0001088514,0.00004568356,0.00001524827,0.001006091,0.00002474993,0.0003582319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006915939,"threshold_uncertainty_score":0.01375133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009363718083812504,"score_gpt":0.2275898279785888,"score_spread":0.2182261098947763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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