{"id":"W2889173752","doi":"10.1016/j.jacl.2018.08.011","title":"Alirocumab dosing patterns during 40 months of open-label treatment in patients with heterozygous familial hypercholesterolemia","year":2018,"lang":"en","type":"article","venue":"Journal of clinical lipidology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission; Regeneron Pharmaceuticals; Sanofi","keywords":"Alirocumab; Medicine; Dosing; Placebo; Familial hypercholesterolemia; Internal medicine; Open label study; Adverse effect; Clinical trial; Open label; Cholesterol; Lipoprotein; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005728037,0.0003074791,0.0009526192,0.000497154,0.0003018446,0.000630925,0.0002139765,0.0005964794,0.0009156312],"category_scores_gemma":[0.002620211,0.0001876846,0.0008177579,0.0006420951,0.0002001249,0.0005537204,0.0002164105,0.0006543305,0.0002487919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005651932,"about_ca_system_score_gemma":0.0003139311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001479476,"about_ca_topic_score_gemma":0.002351806,"domain_scores_codex":[0.9993713,0.0001446149,0.0001022795,0.00016259,0.0001178781,0.0001013225],"domain_scores_gemma":[0.998635,0.000395578,0.0006430468,0.00008489258,0.00009179959,0.0001495839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03461207,0.0005545861,0.9017623,0.0001374022,0.0009575938,0.001013541,0.0003124714,0.0007301944,0.007722355,0.00007870366,0.0008715541,0.05124719],"study_design_scores_gemma":[0.0002996972,0.001890565,0.994316,0.00002066963,0.0003579095,0.0009014162,0.0001053765,0.0007431342,0.0004377657,0.00007398873,0.0008292958,0.00002424982],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997928,0.001187428,0.00009998177,0.0000737678,0.00001244575,0.000009588565,0.0002567236,0.0000131989,0.000418813],"genre_scores_gemma":[0.9990916,0.0001834072,0.00009049207,0.00008619633,0.00002062064,0.00001057693,0.0003480299,0.000005215396,0.0001638599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001479476,"threshold_uncertainty_score":0.00410074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0677263020277176,"score_gpt":0.3912773817947477,"score_spread":0.3235510797670301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}