{"id":"W2889177969","doi":"10.1007/978-1-4939-8651-4_32","title":"Morpholino-Mediated Exon Skipping Targeting Human ACVR1/ALK2 for Fibrodysplasia Ossificans Progressiva","year":2018,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Fibrodysplasia ossificans progressiva; Morpholino; Myositis ossificans; Heterotopic ossification; Exon; Medicine; Ossification; Bioinformatics; Cancer research; Gene knockdown; Biology; Pathology; Genetics; Gene; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004416599,0.0003519504,0.0002059573,0.000292625,0.0003352907,0.0004164256,0.0003894269,0.0006811662,0.001555402],"category_scores_gemma":[0.0001841212,0.0002913231,0.0003737493,0.0001166513,0.0004352605,0.0002881643,0.0002955674,0.0006733214,0.0005126071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003401588,"about_ca_system_score_gemma":0.0003787621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005598363,"about_ca_topic_score_gemma":0.001167577,"domain_scores_codex":[0.9997512,0.00004466121,0.00003251122,0.00005457924,0.00006812991,0.00004890861],"domain_scores_gemma":[0.9999003,0.00002665013,0.00003234683,0.00001584228,0.000008198544,0.00001662398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008269005,0.00002423548,0.00005751216,0.00003966407,0.000005411031,0.000138871,0.00001629231,0.00009528338,0.9977751,0.0003184909,0.00007183175,0.001374655],"study_design_scores_gemma":[0.00005623937,0.0001679753,0.0007433501,0.000006953524,0.00003701185,0.001036931,0.00001995927,0.001128903,0.99033,0.00007798477,0.006385841,0.000008805231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728117,0.003306157,0.01680022,0.0003921522,0.0002156184,0.0002395533,0.0004758363,0.0003735579,0.005385267],"genre_scores_gemma":[0.9845399,0.00101339,0.009221333,0.0001251834,0.00001645322,0.00008208599,0.0005495481,0.00005312754,0.004398962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555402,"threshold_uncertainty_score":0.005203366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0440539712513361,"score_gpt":0.4611845499549108,"score_spread":0.4171305787035747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}