{"id":"W2889227612","doi":"10.1074/jbc.ra118.002754","title":"Overexpression of quality control proteins reduces prion conversion in prion-infected cells","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Alberta Innovates; Killam Trusts; Alberta Innovates - Health Solutions","keywords":"Endoplasmic reticulum; Scrapie; Biology; Cell biology; Cell; Prion protein; Unfolded protein response; Cell culture; In vitro; Virology; Disease; Biochemistry; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002664855,0.0003360509,0.0003772452,0.0002434523,0.0001034254,0.0004447622,0.000214635,0.0003555884,0.00106238],"category_scores_gemma":[0.0002995609,0.0001725488,0.0002532336,0.000205087,0.0002618631,0.0002775992,0.0002443136,0.0007229335,0.0004193318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202046,"about_ca_system_score_gemma":0.0001681744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003922322,"about_ca_topic_score_gemma":0.0003358238,"domain_scores_codex":[0.9997695,0.00004001459,0.00004477718,0.00004449181,0.00005869431,0.00004249072],"domain_scores_gemma":[0.9995707,0.0001263124,0.00008982576,0.00007167616,0.0000510063,0.00009053062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000431253,0.0000187363,0.0000556221,0.0000243398,0.000003141568,0.00003295069,0.000008387883,0.00002151186,0.9993941,0.00002414139,0.00001458253,0.0003593692],"study_design_scores_gemma":[0.00001565824,0.0002756974,0.002867331,0.000008868948,0.00002181396,0.0002851412,0.00001889026,0.0006523902,0.994766,0.00003087818,0.001053552,0.000003848858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936146,0.001578738,0.003239413,0.00009471627,0.00003433145,0.00002907646,0.0004172913,0.0001487004,0.000843081],"genre_scores_gemma":[0.9915996,0.001024682,0.00383079,0.00005004101,0.00001234684,0.00002672468,0.001067892,0.00005168593,0.002336429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00106238,"threshold_uncertainty_score":0.003554046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166325475180861,"score_gpt":0.2850304283262608,"score_spread":0.2683978808081747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}