{"id":"W2889247263","doi":"10.1007/978-1-4939-8651-4_16","title":"Systemic Injection of Peptide-PMOs into Humanized DMD Mice and Evaluation by RT-PCR and ELISA","year":2018,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Duchenne muscular dystrophy; Exon skipping; Morpholino; Exon; Medicine; Peptide; Cardiomyopathy; Molecular biology; Chemistry; Heart failure; Internal medicine; Biochemistry; Gene knockdown; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001169027,0.001359334,0.0006930887,0.000889509,0.000353818,0.0004354996,0.0004253766,0.0009996245,0.002666977],"category_scores_gemma":[0.0002853843,0.0004844859,0.0007324817,0.0005791329,0.0007909901,0.0004213788,0.0002162439,0.002275981,0.001043761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002756518,"about_ca_system_score_gemma":0.0003227028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002710776,"about_ca_topic_score_gemma":0.0005608401,"domain_scores_codex":[0.9990032,0.0001438745,0.00008717914,0.0003325535,0.0001969392,0.0002361736],"domain_scores_gemma":[0.9994941,0.0001791069,0.0001006693,0.0000862851,0.00006623555,0.00007360604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002946307,0.000157653,0.0001742153,0.0000541456,0.000009409409,0.00006215542,0.00002662126,0.0001053299,0.9976916,0.0001315972,0.00008850207,0.001204144],"study_design_scores_gemma":[0.0001086236,0.001754847,0.002405459,0.00001357707,0.00005626564,0.0003195202,0.0000311457,0.00123634,0.9920843,0.0001411064,0.001837441,0.00001154403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8360784,0.004280365,0.1395019,0.0005415238,0.0005819473,0.002476525,0.007574737,0.001692229,0.007272257],"genre_scores_gemma":[0.8030325,0.004322368,0.1549947,0.0005556915,0.0004379324,0.004468998,0.01016485,0.000350499,0.02167252],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002666977,"threshold_uncertainty_score":0.008921921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01553824252095959,"score_gpt":0.3825308926468831,"score_spread":0.3669926501259235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}