{"id":"W2889291379","doi":"10.1016/j.celrep.2018.07.098","title":"A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Peking University; Canadian Institutes of Health Research; National Institutes of Health; Tsinghua University; National Natural Science Foundation of China","keywords":"Calpain; Inflammasome; Cell biology; Extracellular; Chemistry; Depolarization; Membrane potential; Biophysics; Intracellular; Hyperpolarization (physics); Biology; Biochemistry; Receptor; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004360008,0.0003177656,0.000462574,0.0002364693,0.0002572428,0.0008728111,0.0005897425,0.000729061,0.004301415],"category_scores_gemma":[0.0005264352,0.000206619,0.0004412306,0.0002631515,0.0004963048,0.0009797697,0.0003332842,0.001748989,0.001066924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005604805,"about_ca_system_score_gemma":0.0004863122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003109504,"about_ca_topic_score_gemma":0.0004591112,"domain_scores_codex":[0.9996711,0.00004541262,0.00003647197,0.00007180926,0.00007088877,0.0001042735],"domain_scores_gemma":[0.9997781,0.0000310153,0.00006838633,0.00004366965,0.00003163121,0.00004727767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006208314,0.0001414289,0.00009791974,0.00009389525,0.00001532688,0.00008489826,0.00002288868,0.00004772345,0.9944583,0.0007675235,0.0004709531,0.003178249],"study_design_scores_gemma":[0.0002917214,0.0003948367,0.00250816,0.00001282796,0.00001815086,0.0006200345,0.00004081132,0.00072836,0.9911873,0.000362741,0.003823975,0.0000111352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598288,0.01103988,0.01451573,0.002261872,0.0008885514,0.0003082611,0.002115532,0.0007281314,0.008313178],"genre_scores_gemma":[0.9921118,0.001486695,0.003071991,0.0002152183,0.00004430122,0.0000819411,0.000568342,0.00004479335,0.002374888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004301415,"threshold_uncertainty_score":0.01438969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003467135743281118,"score_gpt":0.1988391120595671,"score_spread":0.195371976316286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}