{"id":"W2889291379","doi":"10.1016/j.celrep.2018.07.098","title":"A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Peking University; Canadian Institutes of Health Research; National Institutes of Health; Tsinghua University; National Natural Science Foundation of China","keywords":"Calpain; Inflammasome; Cell biology; Extracellular; Chemistry; Depolarization; Membrane potential; Biophysics; Intracellular; Hyperpolarization (physics); Biology; Biochemistry; Receptor; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002729705,0.0001483605,0.0001773302,0.00004795282,0.00007670367,0.00001520524,0.00004939277,0.0001854213,0.00006648605],"category_scores_gemma":[0.00007065229,0.0001449286,0.00008078363,0.00005926657,0.0001985296,0.000007579162,0.0001222713,0.0000735691,0.000003573951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001111632,"about_ca_system_score_gemma":0.0001214954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001167156,"about_ca_topic_score_gemma":0.00008026905,"domain_scores_codex":[0.9988191,0.00004058408,0.0004034634,0.0003554815,0.000154094,0.0002272748],"domain_scores_gemma":[0.9991441,0.000005507293,0.0002251708,0.00040067,0.0001516874,0.00007284088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007985939,0.00004195121,0.001023415,0.00004140639,0.00002822835,0.0001602243,0.00007798949,0.00001371432,0.9972876,0.0000086808,0.0008954984,0.0003414198],"study_design_scores_gemma":[0.000420223,0.0002813368,0.001645866,0.00002053104,0.00003602935,0.0003122737,0.00009457867,0.00001528906,0.9907369,0.00007326965,0.006188078,0.0001756102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958121,0.0005698368,0.00007874998,0.00006152962,0.0002063483,0.0001716239,0.000004218413,0.00001080608,0.003084803],"genre_scores_gemma":[0.9972339,0.0001801978,0.0001273604,0.00007291573,0.0001705439,0.000007938273,0.0001065353,0.00002009386,0.002080467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006550698,"threshold_uncertainty_score":0.5910018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003467135743281118,"score_gpt":0.1988391120595671,"score_spread":0.195371976316286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}