{"id":"W2889377600","doi":"10.1038/s41586-018-0466-7","title":"Role of glutamine synthetase in angiogenesis beyond glutamine synthesis","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Engineering and Physical Sciences Research Council; National Institutes of Health; Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Sun Yat-sen University; Partnership for Advanced Computing in Europe AISBL; National Natural Science Foundation of China; National Cancer Institute; British Heart Foundation; State Key Laboratory of Ophthalmology; Landsteiner Foundation for Blood Transfusion Research; Australian Government; Fondation contre le Cancer","keywords":"Angiogenesis; Glutamine; Glutamine synthetase; Endothelial stem cell; Cell biology; Umbilical vein; Gene knockdown; Chemistry; Palmitoylation; Biology; Biochemistry; Enzyme; Cancer research; Amino acid; Apoptosis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000329137,0.0002657869,0.0002294406,0.0003123143,0.0002435798,0.0007237252,0.0002644982,0.0005553455,0.001046443],"category_scores_gemma":[0.0002126159,0.00009205997,0.0001741827,0.0002265048,0.0007000083,0.0007989868,0.0003842719,0.0005836071,0.0001973489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007224349,"about_ca_system_score_gemma":0.0006597372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007681875,"about_ca_topic_score_gemma":0.0009687764,"domain_scores_codex":[0.9999052,0.00002829646,0.000006130262,0.00001863217,0.00001739622,0.00002432104],"domain_scores_gemma":[0.999804,0.00004410342,0.00003806701,0.00001844634,0.00003169693,0.0000638073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001080891,0.0001193592,0.0057828,0.0004587831,0.00007021068,0.001889787,0.0001413972,0.002103562,0.8244559,0.08938041,0.002804866,0.07171205],"study_design_scores_gemma":[0.0001687672,0.001832223,0.0394194,0.000259057,0.0001256953,0.005717348,0.0007081324,0.008757683,0.695447,0.1098706,0.1376037,0.00009031021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6465436,0.2579561,0.04172244,0.02171649,0.001539299,0.00005094975,0.0004324769,0.0003048923,0.02973371],"genre_scores_gemma":[0.9558097,0.03216919,0.005258938,0.000499875,0.000360803,0.00001697594,0.0001215262,0.00001659773,0.005746422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046443,"threshold_uncertainty_score":0.005241692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00328682033937233,"score_gpt":0.2283272630913622,"score_spread":0.2250404427519898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}