{"id":"W2889377600","doi":"10.1038/s41586-018-0466-7","title":"Role of glutamine synthetase in angiogenesis beyond glutamine synthesis","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Engineering and Physical Sciences Research Council; National Institutes of Health; Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Sun Yat-sen University; Partnership for Advanced Computing in Europe AISBL; National Natural Science Foundation of China; National Cancer Institute; British Heart Foundation; State Key Laboratory of Ophthalmology; Landsteiner Foundation for Blood Transfusion Research; Australian Government; Fondation contre le Cancer","keywords":"Angiogenesis; Glutamine; Glutamine synthetase; Endothelial stem cell; Cell biology; Umbilical vein; Gene knockdown; Chemistry; Palmitoylation; Biology; Biochemistry; Enzyme; Cancer research; Amino acid; Apoptosis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656214,0.0001644626,0.0002410597,0.0001047034,0.00003306493,0.000007037973,0.0002251629,0.0008533346,0.00008366382],"category_scores_gemma":[0.000248274,0.0001516424,0.0001310174,0.000225618,0.0001200479,0.000004138979,0.00008533035,0.000235764,0.000009034622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001159012,"about_ca_system_score_gemma":0.00006321302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005255558,"about_ca_topic_score_gemma":0.000348596,"domain_scores_codex":[0.9990218,0.00004411905,0.0002007369,0.0003312717,0.0001545708,0.0002474603],"domain_scores_gemma":[0.999289,0.00002176817,0.0000833801,0.0004176534,0.0001185298,0.00006971938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001439364,0.00008854635,0.0009270275,0.0000179936,0.00004929335,0.000001094128,0.00004347575,0.000002975448,0.9664446,0.00008704021,0.003194906,0.02899908],"study_design_scores_gemma":[0.0002964298,0.00007593504,0.0094894,0.00001837887,0.00004134432,0.00001025608,0.00005079075,0.00001443805,0.7638267,0.00006529441,0.2259607,0.0001503382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968342,0.02832223,0.00001623731,0.0001414791,0.0005240964,0.0001336753,0.0001858998,0.000009751192,0.002324637],"genre_scores_gemma":[0.996212,0.0007729993,0.000543488,0.0003170112,0.001636153,0.00002080099,0.00005005913,0.00002654723,0.0004209568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2227658,"threshold_uncertainty_score":0.6581697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00328682033937233,"score_gpt":0.2283272630913622,"score_spread":0.2250404427519898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}