{"id":"W2889452210","doi":"10.1083/jcb.201808118","title":"Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration","year":2018,"lang":"en","type":"letter","venue":"The Journal of Cell Biology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hewitt Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"Parkin; PINK1; Neurodegeneration; Mitophagy; Inflammation; Proinflammatory cytokine; Mitochondrial DNA; Disease; Mitochondrion; Biology; Medicine; Genetics; Parkinson's disease; Gene; Immunology; Internal medicine; Autophagy; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008520149,0.0004637037,0.0006774847,0.0002821129,0.001146607,0.0009996673,0.0005628735,0.01269646,0.005064136],"category_scores_gemma":[0.006989977,0.0002279155,0.0004680761,0.0001802547,0.001100901,0.0012479,0.0006644293,0.01046337,0.004440137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00129151,"about_ca_system_score_gemma":0.0005444615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006014695,"about_ca_topic_score_gemma":0.0009414151,"domain_scores_codex":[0.9994714,0.0001878587,0.00007263954,0.00006857895,0.0001297799,0.00006975584],"domain_scores_gemma":[0.9982394,0.001001959,0.0001736712,0.0001010047,0.0002690477,0.0002149868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003074852,0.0001372957,0.001395117,0.0001362981,0.00002413745,0.01389155,0.0001934726,0.0001062807,0.001680584,0.004535936,0.9391051,0.03848679],"study_design_scores_gemma":[0.0003426455,0.0003518143,0.003309603,0.0003236378,0.00004828399,0.02283823,0.0004138777,0.00100919,0.002449904,0.02103119,0.947823,0.00005871532],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.004589606,0.00768234,0.0003099577,0.9500997,0.03221688,0.00002070374,0.00008446365,0.0000885749,0.004907689],"genre_scores_gemma":[0.08960868,0.01464717,0.0009425204,0.6704945,0.1965612,0.00009709033,0.0001292698,0.0000646951,0.02745494],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01269646,"threshold_uncertainty_score":0.01694119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009839772544269744,"score_gpt":0.2225702374213588,"score_spread":0.212730464877089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}