{"id":"W2889453206","doi":"10.1016/j.humimm.2018.07.026","title":"OR21 HLA-C downregulation by HIV adapts to host HLA genotype","year":2018,"lang":"en","type":"article","venue":"Human Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"","keywords":"Downregulation and upregulation; Viral quasispecies; Human leukocyte antigen; Biology; Virology; Viral load; Immunology; Virus; Gene; Genetics; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002484413,0.0002964649,0.0002310374,0.0002065079,0.0003364985,0.0009726759,0.0002621091,0.0004036893,0.006280675],"category_scores_gemma":[0.0005732315,0.0001354536,0.0002417091,0.0001705589,0.0002674492,0.0003616135,0.0005795493,0.0006014609,0.001016686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003184537,"about_ca_system_score_gemma":0.0002059725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004755947,"about_ca_topic_score_gemma":0.0003759325,"domain_scores_codex":[0.9995771,0.00008277084,0.00002370692,0.00005153449,0.00004309742,0.0002216863],"domain_scores_gemma":[0.999823,0.00003184713,0.00003902963,0.00004162881,0.00001972009,0.00004487282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007811734,0.0001607681,0.008318713,0.00005032788,0.00002159556,0.0004078148,0.00009344826,0.0001425775,0.975679,0.0007992157,0.0003655101,0.01317984],"study_design_scores_gemma":[0.0001702642,0.002243889,0.3905073,0.0000829144,0.0001341492,0.00527128,0.001079732,0.004546219,0.5694001,0.00211611,0.02440058,0.00004750479],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941161,0.001204112,0.0003713445,0.0001081866,0.00005498382,0.00001755257,0.00009839134,0.00001727086,0.004012045],"genre_scores_gemma":[0.9971563,0.0004786956,0.0001723132,0.00008345873,0.00003119241,0.00001401358,0.0001655714,0.00001212106,0.001886459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006280675,"threshold_uncertainty_score":0.02101088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663215550818815,"score_gpt":0.2759787608623988,"score_spread":0.2593466053542106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}