{"id":"W2889458643","doi":"10.1016/j.neulet.2018.08.038","title":"Soluble TREM2 changes during the clinical course of Alzheimer’s disease: A meta-analysis","year":2018,"lang":"en","type":"review","venue":"Neuroscience Letters","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; Brain and Cognition Discovery Foundation; University Health Network","funders":"Natural Science Foundation of Beijing Municipality; National Natural Science Foundation of China","keywords":"TREM2; Medicine; Meta-analysis; Internal medicine; Cochrane Library; Strictly standardized mean difference; Biomarker; Oncology; Neuroinflammation; Subgroup analysis; Dementia; Clinical Dementia Rating; Alzheimer's disease; Cohort; Disease; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003185686,0.001762209,0.006330394,0.00111591,0.0003175412,0.001391069,0.001126492,0.001235339,0.001653351],"category_scores_gemma":[0.005327526,0.0006697183,0.01303943,0.002232422,0.0003093076,0.0008118296,0.0009212721,0.001174223,0.000176348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005469345,"about_ca_system_score_gemma":0.0006995295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002769026,"about_ca_topic_score_gemma":0.005965114,"domain_scores_codex":[0.9983565,0.0006041272,0.0003550854,0.000435403,0.0001451517,0.0001036302],"domain_scores_gemma":[0.9975279,0.001548907,0.0004571213,0.0001900851,0.0002065383,0.00006946819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0137215,0.00009707679,0.07984839,0.06754141,0.7829004,0.000442698,0.0001420594,0.0008794334,0.001081611,0.0002538223,0.001696925,0.0513947],"study_design_scores_gemma":[0.0007702406,0.0005481211,0.07429761,0.003586814,0.9157068,0.0003801472,0.00008703618,0.0003333363,0.0002409809,0.0004586382,0.003538382,0.00005191665],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03888236,0.9593897,0.0005258726,0.0001861527,0.0001729464,0.00003187164,0.0005967792,0.0000158985,0.0001983025],"genre_scores_gemma":[0.5472712,0.4475871,0.001590669,0.0008421594,0.0004433636,0.0001505631,0.001513143,0.00002721211,0.0005745356],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006330394,"threshold_uncertainty_score":0.01684773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3791645285029093,"score_gpt":0.4279336414662455,"score_spread":0.04876911296333614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}