{"id":"W2889462798","doi":"10.1007/978-1-4939-8651-4_9","title":"In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient","year":2018,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"Exon skipping; Exon; Duchenne muscular dystrophy; Morpholino; Dystrophin; Myogenesis; Molecular biology; Biology; Muscular dystrophy; Antisense therapy; Cell biology; Chemistry; Alternative splicing; Genetics; Myocyte; Gene knockdown; Cell culture; Oligonucleotide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581987,0.000225333,0.0002245133,0.0001950635,0.0002126374,0.0001344226,0.0001507202,0.0003918495,0.001143746],"category_scores_gemma":[0.0002159496,0.0001499213,0.0002812988,0.00008901147,0.0001805845,0.00008994673,0.0001721155,0.0003460213,0.0002177179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000140921,"about_ca_system_score_gemma":0.0001383005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008941669,"about_ca_topic_score_gemma":0.0009692352,"domain_scores_codex":[0.9998566,0.00002366078,0.00002278136,0.00005110913,0.00002015539,0.00002575837],"domain_scores_gemma":[0.9998887,0.00006097849,0.00001090544,0.00001125661,0.000008373711,0.00001992626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001662198,0.00003648367,0.001677167,0.00003613395,0.000008863893,0.003255478,0.0001012921,0.000168438,0.9925695,0.0001622532,0.00005729078,0.001760753],"study_design_scores_gemma":[0.00006988997,0.001052639,0.02536293,0.000009853223,0.0001409707,0.01732634,0.0001388548,0.002831686,0.9484926,0.0002362265,0.004326025,0.00001201655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962669,0.0003168938,0.002149322,0.00008596009,0.00002757635,0.0000183348,0.0001868952,0.0000351187,0.0009130556],"genre_scores_gemma":[0.9966736,0.0002513278,0.001552121,0.00004605787,0.000009083217,0.00001528569,0.0003523148,0.00001324211,0.001087051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143746,"threshold_uncertainty_score":0.003826261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008910248923750346,"score_gpt":0.3443169859649195,"score_spread":0.3354067370411691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}