{"id":"W2889524763","doi":"10.1016/j.hbpd.2018.08.008","title":"Insulin-like growth factor binding protein related protein 1 knockdown attenuates hepatic fibrosis via the regulation of MMPs/TIMPs in mice","year":2018,"lang":"en","type":"article","venue":"Hepatobiliary & pancreatic diseases international","topic":"Liver physiology and pathology","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"National Natural Science Foundation of China","keywords":"Medicine; Insulin-like growth factor-binding protein; Gene knockdown; Matrix metalloproteinase; Insulin-like growth factor; Insulin; Fibrosis; Growth factor; Internal medicine; Cancer research; Endocrinology; Pharmacology; Biochemistry; Receptor; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002272658,0.00025647,0.0004406083,0.0002592863,0.0001143019,0.00001430551,0.0002952424,0.00016716,0.001067125],"category_scores_gemma":[0.0005795007,0.0001901006,0.0001685652,0.0003751162,0.0006285755,0.0002276175,0.0001212162,0.0002402631,0.0001447959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151328,"about_ca_system_score_gemma":0.0001650463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003169977,"about_ca_topic_score_gemma":0.00002872531,"domain_scores_codex":[0.9978495,0.0003477681,0.0006884505,0.0004474783,0.0003778954,0.0002888997],"domain_scores_gemma":[0.9985757,0.0002757801,0.0003340711,0.0003715683,0.0003353282,0.0001075691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001486469,0.0006995661,0.6041518,0.0002383607,0.0003398389,0.0000266391,0.0007247275,0.000004467689,0.3901812,0.001057392,0.0001861713,0.0009034138],"study_design_scores_gemma":[0.002032745,0.0007091362,0.9398861,0.00101058,0.0002374359,0.0000508768,0.00009298416,0.00593984,0.04278724,0.006903078,0.00007955793,0.0002704527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965192,0.0001819246,0.00006401454,0.0006864377,0.0002866554,0.001419479,0.0001479234,0.00006658103,0.0006277983],"genre_scores_gemma":[0.9975315,0.00002669789,0.0005095007,0.0001514421,0.0001890091,0.0002770555,0.0003721536,0.00003042361,0.0009121947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.347394,"threshold_uncertainty_score":0.999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107974389911812,"score_gpt":0.2496578635997527,"score_spread":0.2388604246085715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}