{"id":"W2889526955","doi":"10.14785/lymphosign-2018-0007","title":"Gene therapy for PNP deficiency protocol","year":2018,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Genetic enhancement; Severe combined immunodeficiency; Adenosine deaminase deficiency; Hematopoietic stem cell transplantation; Transplantation; Viral vector; Immune system; Medicine; Purine nucleoside phosphorylase; Immunology; Salvage therapy; Stem cell; Purine; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006662006,0.0001594016,0.0001188387,0.00006748009,0.000353507,0.00008562678,0.0004180837,0.0001175931,0.0001798498],"category_scores_gemma":[0.00004584577,0.0001275069,0.0001447193,0.0001071416,0.0001404846,0.000005249361,0.00004146886,0.00007874979,0.00003259552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004037001,"about_ca_system_score_gemma":0.0004442663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002053396,"about_ca_topic_score_gemma":0.000006974497,"domain_scores_codex":[0.9987062,0.00008230521,0.0002375552,0.0002734486,0.0002349155,0.000465608],"domain_scores_gemma":[0.9990705,0.00001150267,0.0001070314,0.000315754,0.000335159,0.0001600959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005241733,0.000114174,0.0002590143,0.000005001756,0.00003911721,0.000002554289,0.00004700286,0.000005851218,0.9357429,0.00001288696,0.01046707,0.0480627],"study_design_scores_gemma":[0.003347601,0.0117484,0.0001175351,0.000006712975,0.00000319257,0.0001728031,0.00001480867,0.00005675207,0.8998201,0.0005947009,0.08394787,0.0001695033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9182422,0.0009968372,0.04111588,0.0004788334,0.0004316614,0.03702754,0.00002385479,0.00003148042,0.001651732],"genre_scores_gemma":[0.9163987,0.0004650098,0.01365803,0.003601047,0.009794533,0.05389484,0.00003981696,0.0002176656,0.001930372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0734808,"threshold_uncertainty_score":0.5199579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03033929232889879,"score_gpt":0.3484591290594232,"score_spread":0.3181198367305244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}