{"id":"W2889526955","doi":"10.14785/lymphosign-2018-0007","title":"Gene therapy for PNP deficiency protocol","year":2018,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Genetic enhancement; Severe combined immunodeficiency; Adenosine deaminase deficiency; Hematopoietic stem cell transplantation; Transplantation; Viral vector; Immune system; Medicine; Purine nucleoside phosphorylase; Immunology; Salvage therapy; Stem cell; Purine; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000953246,0.0009766081,0.0008895218,0.0009621639,0.0009517876,0.0005911455,0.001067439,0.001688157,0.04562588],"category_scores_gemma":[0.0005522317,0.0003125076,0.0008882047,0.0004834205,0.0006718612,0.0004921003,0.000795783,0.00238616,0.008550582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006698882,"about_ca_system_score_gemma":0.001601081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004490206,"about_ca_topic_score_gemma":0.000916226,"domain_scores_codex":[0.9992518,0.0001681302,0.00007939045,0.000151957,0.0002295955,0.0001192217],"domain_scores_gemma":[0.9997316,0.00004085853,0.0000311413,0.00006890365,0.00006029718,0.00006717821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.011282,0.008094708,0.001127683,0.003069843,0.0001855711,0.00219234,0.0003583505,0.001857676,0.5891399,0.01920529,0.08982329,0.2736634],"study_design_scores_gemma":[0.005106643,0.01689447,0.002654985,0.0005076559,0.0003374971,0.00794515,0.00009075272,0.001552823,0.3208016,0.003361706,0.6406229,0.0001238153],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"protocol","genre_scores_codex":[0.2183964,0.03704099,0.278547,0.005719274,0.007417564,0.1978043,0.03140096,0.007287746,0.2163859],"genre_scores_gemma":[0.2496509,0.02847915,0.2265776,0.005439583,0.0009264291,0.2369872,0.03065127,0.0007590653,0.2205288],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.04562588,"threshold_uncertainty_score":0.1526337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03033929232889879,"score_gpt":0.3484591290594232,"score_spread":0.3181198367305244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}