{"id":"W2889543660","doi":"10.1074/jbc.ra118.002640","title":"Membrane cholesterol as regulator of human rhomboid protease RHBDL4","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Alzheimer's Society; Canada Foundation for Innovation; Alzheimer Society; Scottish Rite Charitable Foundation of Canada; Government of Canada","keywords":"Proteases; Cholesterol; Biochemistry; Serine; Amyloid precursor protein; Biology; Endogeny; Transmembrane protein; Rhomboid; Tyrosine; Regulator; Enzyme; Cell biology; Chemistry; Alzheimer's disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484061,0.0002435793,0.0002230601,0.0001966887,0.000133531,0.000291566,0.0001868882,0.0002208795,0.0009153172],"category_scores_gemma":[0.0001752989,0.00008883814,0.0001843124,0.000109064,0.00022864,0.0001263292,0.0002074244,0.0003132301,0.0004484122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003567162,"about_ca_system_score_gemma":0.0002064483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005774295,"about_ca_topic_score_gemma":0.0005143998,"domain_scores_codex":[0.9998327,0.00004510778,0.00001659764,0.00002672835,0.00004365288,0.00003519221],"domain_scores_gemma":[0.9999202,0.00001847596,0.0000233268,0.000009621709,0.00001399585,0.00001429649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001419971,0.00001202129,0.0001746529,0.00002663941,0.000002393112,0.00006492675,0.000008294359,0.00002717767,0.9989755,0.00006743359,0.00002000092,0.0004790449],"study_design_scores_gemma":[0.00002732861,0.0001024907,0.002805313,0.000003964364,0.00001029256,0.0001960254,0.0000200857,0.0006371104,0.9942096,0.00006876023,0.001914746,0.000004211737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909108,0.004502142,0.002467428,0.0002077708,0.00003875136,0.000035113,0.000257588,0.00008043403,0.001499919],"genre_scores_gemma":[0.9953995,0.001152326,0.001728463,0.00005499372,0.000009375176,0.0000270351,0.0003101143,0.00001317158,0.001305064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009153172,"threshold_uncertainty_score":0.003062069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04343940691721628,"score_gpt":0.3440540519811403,"score_spread":0.300614645063924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}