{"id":"W2889553363","doi":"10.1002/hep.30237","title":"Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease","year":2018,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Toronto Liver Centre","funders":"","keywords":"Primary sclerosing cholangitis; Natural history; Disease; Medicine; Primary (astronomy); Gastroenterology; Internal medicine; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022081,0.0001098581,0.0002062256,0.00003831445,0.0001479276,0.000004266991,0.0001582572,0.00003086342,0.0000188114],"category_scores_gemma":[0.0001959862,0.00005119198,0.00008193638,0.00007813302,0.0004127646,0.00004428149,0.00005797249,0.0001570139,0.000004640542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000211517,"about_ca_system_score_gemma":0.0004783554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001034117,"about_ca_topic_score_gemma":0.00003585779,"domain_scores_codex":[0.9991586,0.0001519848,0.000178513,0.0001870025,0.0001616115,0.0001622948],"domain_scores_gemma":[0.9988735,0.0001828899,0.0001193468,0.0005986472,0.0001555303,0.00007007805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1920836,0.02458657,0.5814421,0.0008834982,0.00216608,0.000365545,0.03615549,0.000002244847,0.007492647,0.005888002,0.1324305,0.01650381],"study_design_scores_gemma":[0.02170659,0.00779693,0.9319351,0.0003415587,0.0009036519,0.00002712715,0.0009410148,0.0008957559,0.0006661544,0.0001624609,0.03438696,0.0002366429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954091,0.0009665978,0.000005034083,0.0008222089,0.0004523569,0.0009914088,0.00003658179,0.00002227717,0.001294476],"genre_scores_gemma":[0.9973221,0.000009028556,0.00001676819,0.001981963,0.0001202923,0.00004095224,0.0000245591,0.00001416103,0.0004701993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3504931,"threshold_uncertainty_score":0.2087549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03601273279223837,"score_gpt":0.278933985815928,"score_spread":0.2429212530236896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}