{"id":"W2889591906","doi":"10.1096/fasebj.30.1_supplement.102.1","title":"Dimer Induced Regulation of Protein Kinase Function","year":2016,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Allosteric regulation; Kinase; ASK1; Protein kinase A; Dimer; Cell biology; Mechanism (biology); Chemistry; Function (biology); Mitogen-activated protein kinase kinase; Biology; Biochemistry; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002421572,0.00006551237,0.00005516752,0.00003315839,0.0000987044,0.000012179,0.0001080157,0.00006234765,0.0001859232],"category_scores_gemma":[0.0001170364,0.00003529736,0.00006874163,0.00004574074,0.00004254601,0.000008402221,0.00003242566,0.00009195371,0.00002277983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001681136,"about_ca_system_score_gemma":0.00004748587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007333811,"about_ca_topic_score_gemma":0.000005285981,"domain_scores_codex":[0.9994316,0.0000976539,0.0001660232,0.00008759632,0.0001142301,0.0001028894],"domain_scores_gemma":[0.9994453,0.000009931095,0.000169998,0.0002115531,0.0001253121,0.00003795625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001522103,0.00002143164,0.0002129843,0.000001714738,0.00003616146,3.651573e-7,0.00001355435,0.000004670127,0.9908702,0.0001086482,0.0004258911,0.008152219],"study_design_scores_gemma":[0.0003414751,0.0002528147,0.004311268,0.00004122019,0.00001587047,0.00005060909,0.00002478531,0.000003413304,0.9913018,0.000744833,0.002857209,0.00005474712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906073,0.00008872588,0.007877018,0.0006196185,0.0002089653,0.0001395934,0.000003692762,0.00000413692,0.0004509815],"genre_scores_gemma":[0.9976179,0.00001120494,0.0001523627,0.00004305248,0.0003599478,0.00001219727,0.000003106176,0.00001003513,0.00179019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008097472,"threshold_uncertainty_score":0.2035729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492239614357199,"score_gpt":0.2460135017803338,"score_spread":0.2310911056367619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}