{"id":"W2889608649","doi":"10.1146/annurev-genet-120417-031311","title":"Calcium Channelopathies: Structural Insights into Disorders of the Muscle Excitation–Contraction Complex","year":2018,"lang":"en","type":"article","venue":"Annual Review of Genetics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Allosteric regulation; Ion channel; Gating; Biophysics; Biology; Ligand-gated ion channel; Membrane protein; Light-gated ion channel; Membrane potential; Voltage-gated ion channel; Voltage-dependent calcium channel; Calcium; Cardiac action potential; Calcium signaling; Cell biology; Electrophysiology; Signal transduction; Neuroscience; Chemistry; Biochemistry; Membrane; Receptor; Repolarization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118158,0.0001005004,0.000144786,0.00002645452,0.00008754286,0.000003197838,0.0001391321,0.00007349758,0.00003681046],"category_scores_gemma":[0.0001340796,0.00007247492,0.0001058949,0.0001566735,0.0002044859,0.000005826899,0.00005955838,0.00004025011,0.000003510159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007982654,"about_ca_system_score_gemma":0.00004553192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001601626,"about_ca_topic_score_gemma":0.00005403665,"domain_scores_codex":[0.9991849,0.00008562055,0.0003136915,0.000153561,0.0001697441,0.00009245543],"domain_scores_gemma":[0.9990001,0.0000100701,0.0002345507,0.0002603894,0.0004642886,0.00003064458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000190194,0.0002039636,0.002342286,0.005302132,0.0002170524,2.500365e-7,0.005529311,0.0003612589,0.7549537,0.001928944,0.02365027,0.2053207],"study_design_scores_gemma":[0.0008579813,0.001201126,0.1784712,0.001149926,0.0001222109,0.000006103855,0.001262491,0.001888031,0.1836392,0.002001565,0.6289488,0.000451415],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965463,0.02599105,0.004760207,0.0008445964,0.001418151,0.0005715736,0.0000306547,0.000008766093,0.0009119616],"genre_scores_gemma":[0.9886573,0.01001451,0.0002630428,0.0005330128,0.0003410629,0.000007189323,0.00007285276,0.00001023721,0.0001008085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6052986,"threshold_uncertainty_score":0.2955441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01587700506920007,"score_gpt":0.291726808452414,"score_spread":0.2758498033832139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}