{"id":"W2889624058","doi":"10.1200/jco.2018.36.15_suppl.10504","title":"Trametinib in pediatric patients with neurofibromatosis type 1 (NF-1)–associated plexiform neurofibroma: A phase I/IIa study.","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Trametinib; Cohort; Internal medicine; Neurofibromatosis; Adverse effect; Stock options; Oncology; Surgery; Gastroenterology; Pathology; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001114313,0.0007748366,0.001197281,0.0002784358,0.000271667,0.0006308191,0.0004843901,0.0005492381,0.001274275],"category_scores_gemma":[0.0005767833,0.0003524398,0.00103367,0.0004302028,0.000344088,0.000537931,0.0002259394,0.001336405,0.0003846641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009937462,"about_ca_system_score_gemma":0.001610116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001469731,"about_ca_topic_score_gemma":0.005439154,"domain_scores_codex":[0.9997546,0.00009611648,0.00001957117,0.00004488857,0.00003274171,0.00005204222],"domain_scores_gemma":[0.999588,0.00005504692,0.0001340322,0.00003063215,0.00003513739,0.0001571163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3874262,0.052958,0.1679213,0.002245983,0.00608668,0.001780695,0.0007991132,0.00980448,0.06489254,0.0004546892,0.01292232,0.292708],"study_design_scores_gemma":[0.2540578,0.4880329,0.224165,0.0002102051,0.003483229,0.004645478,0.0002902018,0.004701626,0.007461299,0.0002762746,0.01260292,0.00007309818],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937902,0.003137445,0.0002345324,0.0001550385,0.00002924885,0.0007296274,0.001034437,0.00003417597,0.0008553177],"genre_scores_gemma":[0.9915438,0.00297841,0.001151199,0.0004067717,0.00005166164,0.0006650211,0.002526805,0.00001354508,0.0006629208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001469731,"threshold_uncertainty_score":0.007210135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09482405278384176,"score_gpt":0.4343018398476142,"score_spread":0.3394777870637724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}