{"id":"W2889642654","doi":"10.1016/j.omtn.2018.09.003","title":"HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins","year":2018,"lang":"en","type":"review","venue":"Molecular Therapy — Nucleic Acids","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Foundation for AIDS Research","keywords":"Fusion protein; Linker; Entry inhibitor; Bifunctional; Viral entry; Lipid bilayer fusion; Potency; Human immunodeficiency virus (HIV); Biology; Plasma protein binding; Computational biology; Cell biology; Chemistry; Biochemistry; Virology; Virus; In vitro; Recombinant DNA; Viral replication; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002773426,0.0006160361,0.0006473813,0.001412549,0.000213298,0.0005575949,0.0005022642,0.0007172303,0.001886879],"category_scores_gemma":[0.0002462819,0.0002178315,0.0003222312,0.0008935534,0.0002552302,0.0006796693,0.0004262948,0.001185286,0.00141996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004445683,"about_ca_system_score_gemma":0.000447004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005281667,"about_ca_topic_score_gemma":0.00071217,"domain_scores_codex":[0.9998715,0.00001557722,0.00001473822,0.0000214747,0.0000573099,0.00001933472],"domain_scores_gemma":[0.9999368,0.00002400976,0.00001087072,0.000002892162,0.00001850512,0.000006915662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007473633,0.0001276119,0.0001949103,0.01399701,0.00006186631,0.0002843148,0.00007916701,0.000442352,0.02178317,0.008363159,0.01835575,0.9362361],"study_design_scores_gemma":[0.000009414725,0.0001073415,0.0005468169,0.001174268,0.00004169025,0.001257881,0.00003124123,0.0001267772,0.006634794,0.001206908,0.9888475,0.00001535752],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005409725,0.9969115,0.000286269,0.0001353325,0.0001475315,0.000007511397,0.00002080941,0.00001188103,0.001938229],"genre_scores_gemma":[0.003295663,0.9945951,0.0003647504,0.0001424473,0.00009298632,0.00001451909,0.00005256895,0.000002468689,0.001439545],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001886879,"threshold_uncertainty_score":0.006312251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921413563901718,"score_gpt":0.2769117883230522,"score_spread":0.2576976526840351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}