{"id":"W2889642654","doi":"10.1016/j.omtn.2018.09.003","title":"HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins","year":2018,"lang":"en","type":"review","venue":"Molecular Therapy — Nucleic Acids","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Foundation for AIDS Research","keywords":"Fusion protein; Linker; Entry inhibitor; Bifunctional; Viral entry; Lipid bilayer fusion; Potency; Human immunodeficiency virus (HIV); Biology; Plasma protein binding; Computational biology; Cell biology; Chemistry; Biochemistry; Virology; Virus; In vitro; Recombinant DNA; Viral replication; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001746498,0.0004810703,0.0007909454,0.0001649426,0.0002387755,0.00004538819,0.0001738635,0.000625085,0.0009816334],"category_scores_gemma":[0.00002087266,0.0003631904,0.0003131047,0.000175388,0.0002467918,0.0000755688,0.0001068167,0.0004728253,0.005021731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008701812,"about_ca_system_score_gemma":0.0001480803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006225182,"about_ca_topic_score_gemma":4.547002e-7,"domain_scores_codex":[0.9979678,0.0004765686,0.0003395831,0.0006138823,0.00009884631,0.000503326],"domain_scores_gemma":[0.9993746,0.00003506718,0.0001513526,0.0003196428,0.00006420659,0.00005516848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002021415,0.0005594431,0.00001710066,0.001072626,0.002232509,0.0001238879,0.00006780118,1.037658e-8,0.02968757,0.000279412,0.02376286,0.9419946],"study_design_scores_gemma":[0.001364579,0.0005586005,0.000007080474,0.0008643842,0.0001202217,0.0001259544,0.00000346673,1.711349e-7,0.008690469,0.00003340292,0.9879093,0.0003224003],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003558252,0.9931533,0.00009759972,0.00007876888,0.0001781634,0.001338919,0.0006319657,0.00007765526,0.0008853475],"genre_scores_gemma":[0.001684574,0.9900541,0.00003889077,0.00009970684,0.00006481689,0.0003069089,0.003967277,0.00007446696,0.003709313],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9641464,"threshold_uncertainty_score":0.9999316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921413563901718,"score_gpt":0.2769117883230522,"score_spread":0.2576976526840351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}