{"id":"W2889677538","doi":"10.1038/s41467-019-09892-6","title":"The extracellular gate shapes the energy profile of an ABC exporter","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Universität Zürich; Eidgenössische Technische Hochschule Zürich; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut für Medizinische Mikrobiologie, Universität Zürich; National Science Foundation","keywords":"Extracellular; Electron transport chain; ATP hydrolysis; Transporter; Biophysics; ATP-binding cassette transporter; Intracellular; Chemistry; ATPase; Transport protein; Adenosine triphosphate; Cell biology; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006106962,0.0000900321,0.000156788,0.00006535255,0.0001499569,0.0003420268,0.0001680907,0.0002065741,0.001197145],"category_scores_gemma":[0.0001178572,0.0001006898,0.000110531,0.00004837663,0.0002635756,0.0002889883,0.0002143716,0.00038224,0.000273275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001836231,"about_ca_system_score_gemma":0.0001106975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002046302,"about_ca_topic_score_gemma":0.0002507097,"domain_scores_codex":[0.9999602,0.000003971908,0.000001900885,0.00001066829,0.00001206545,0.00001121442],"domain_scores_gemma":[0.9999484,0.0000130532,0.0000106565,0.00000451832,0.000008604196,0.00001488594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002646582,0.000006450372,0.0002599757,0.000007391806,0.000001553893,0.0000509773,0.00001176472,0.0003545481,0.9977818,0.0005589952,0.00003053877,0.0009095173],"study_design_scores_gemma":[0.00002251213,0.0001330118,0.003311226,0.000003978936,0.000008616437,0.0002909026,0.00007917229,0.01740777,0.9761401,0.0006616938,0.001929766,0.00001129967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948607,0.00005688939,0.003935803,0.00006176199,0.000005625244,0.000002123624,0.0000255708,0.000027295,0.001024197],"genre_scores_gemma":[0.9981011,0.00003785983,0.001339688,0.00002827149,0.000001363307,0.000002102601,0.00002832254,0.00001227708,0.0004490238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001197145,"threshold_uncertainty_score":0.004004896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194396655091438,"score_gpt":0.2667935426760215,"score_spread":0.2548495761251071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}