{"id":"W2889677538","doi":"10.1038/s41467-019-09892-6","title":"The extracellular gate shapes the energy profile of an ABC exporter","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Universität Zürich; Eidgenössische Technische Hochschule Zürich; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut für Medizinische Mikrobiologie, Universität Zürich; National Science Foundation","keywords":"Extracellular; Electron transport chain; ATP hydrolysis; Transporter; Biophysics; ATP-binding cassette transporter; Intracellular; Chemistry; ATPase; Transport protein; Adenosine triphosphate; Cell biology; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002927411,0.00008767137,0.0001355744,0.00002698717,0.0002667971,0.00001396135,0.0008221332,0.0001459826,0.00009949815],"category_scores_gemma":[0.00001457128,0.00004335549,0.00008946753,0.0001583559,0.000164553,0.00005185814,0.00005731227,0.0005127958,0.00001472417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000115301,"about_ca_system_score_gemma":0.00006363467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001372847,"about_ca_topic_score_gemma":0.0003066187,"domain_scores_codex":[0.9992715,0.00006978124,0.0002118312,0.0001105544,0.0002039416,0.0001324606],"domain_scores_gemma":[0.9976351,0.0001356112,0.0001025052,0.001944911,0.000138745,0.00004313277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002971903,0.0009295741,0.00414153,0.00008224075,0.0003455534,0.000009004229,0.002154348,0.00002257665,0.2290959,0.7339188,0.004424941,0.02457832],"study_design_scores_gemma":[0.0007564645,0.0001403539,0.02641007,0.0001177759,0.0001677071,0.00001894845,0.001595128,0.003127847,0.02454784,0.001793355,0.941149,0.0001754877],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6744119,0.1509779,0.0008138485,0.05625516,0.001079346,0.002615578,0.00009548871,0.0002951298,0.1134557],"genre_scores_gemma":[0.9890004,0.001121259,0.001491138,0.0003221804,0.00003659995,0.00004547486,0.0001023848,0.00001629089,0.007864213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9367241,"threshold_uncertainty_score":0.2227871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194396655091438,"score_gpt":0.2667935426760215,"score_spread":0.2548495761251071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}