{"id":"W2889704941","doi":"10.1242/jeb.181529","title":"Taurine activates glycine and GABAA receptor currents in anoxia-tolerant painted turtle pyramidal neurons","year":2018,"lang":"en","type":"article","venue":"Journal of Experimental Biology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"GABAA receptor; Picrotoxin; Glycine receptor; Strychnine; Inhibitory postsynaptic potential; Taurine; Biology; Patch clamp; GABAB receptor; gamma-Aminobutyric acid; GABAA-rho receptor; Receptor; Chemistry; Neuroscience; Glycine; Electrophysiology; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222093,0.0001568906,0.0002373976,0.00009225916,0.00004244857,0.000009706268,0.0001284978,0.0001136223,0.0001080163],"category_scores_gemma":[0.00004904387,0.0001230144,0.00006559173,0.00007168479,0.0002429077,0.000009563497,0.000120485,0.0001374758,0.000005560243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002215711,"about_ca_system_score_gemma":0.00003862865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001791745,"about_ca_topic_score_gemma":0.000005850988,"domain_scores_codex":[0.9990906,0.00008612526,0.0003271567,0.0002093053,0.00006085234,0.0002259537],"domain_scores_gemma":[0.9995324,0.00001273781,0.0001719804,0.0001234754,0.00005904617,0.0001003821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005590263,0.0002508012,0.005975592,0.000003343987,0.00005033386,0.00001136585,0.0001026297,4.063335e-7,0.9912265,0.00001997193,0.0008633572,0.0009366626],"study_design_scores_gemma":[0.001507387,0.002532108,0.001483778,0.00002390145,0.000006766759,0.0002264347,0.0002740887,0.00001727844,0.9772924,0.00002310159,0.01648289,0.0001298433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959164,0.003104917,0.00002221746,0.0002480029,0.0004657508,0.00008167365,0.00001364013,0.00000335609,0.0001440701],"genre_scores_gemma":[0.9983872,0.0003466539,0.0002802415,0.0001927909,0.000697018,0.000002963516,0.00003933184,0.0000140434,0.00003977308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01561953,"threshold_uncertainty_score":0.5016382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116063722963853,"score_gpt":0.2935060425419197,"score_spread":0.2823454053122812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}