{"id":"W2889722634","doi":"10.1101/425199","title":"Cellular senescence is a central response to cytotoxic chemotherapy in high-grade serous ovarian cancer","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Cancer Research; Fonds de Recherche du Québec - Santé; Cancer Research Society; Canadian Institutes of Health Research; Mitacs; Terry Fox Research Institute; Ovarian Cancer Canada","keywords":"Senescence; Serous ovarian cancer; Chemotherapy; DNA damage; Ovarian cancer; Cancer research; Serous fluid; Medicine; Cancer; Biology; Oncology; Internal medicine; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004043013,0.0001536875,0.0001856683,0.0003182,0.0001691444,0.0004458255,0.00009044481,0.0002500582,0.002138411],"category_scores_gemma":[0.0004248463,0.00008576635,0.000120297,0.0002531515,0.0001897205,0.000137269,0.0002112042,0.0003519003,0.0004373734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002313849,"about_ca_system_score_gemma":0.0001855521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000222924,"about_ca_topic_score_gemma":0.0002982225,"domain_scores_codex":[0.9998914,0.00002621689,0.00001207452,0.00001857567,0.00003726058,0.00001441148],"domain_scores_gemma":[0.9997547,0.00004757399,0.00008709924,0.00002730389,0.00003988226,0.00004332871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001322538,0.00008195249,0.05697999,0.0005147406,0.0000488193,0.00111089,0.0002409898,0.0003328684,0.8896632,0.0006977497,0.006227106,0.04277923],"study_design_scores_gemma":[0.00007493242,0.0009694678,0.4267497,0.00008543688,0.00006963911,0.006552129,0.000444399,0.001492856,0.519331,0.0009631318,0.04324531,0.00002198862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802902,0.009716008,0.002398799,0.002015367,0.0003643762,0.00004301267,0.001235679,0.000224228,0.003712368],"genre_scores_gemma":[0.9918903,0.003230702,0.0009779886,0.0003020506,0.0001714905,0.00001468436,0.000882454,0.00002100159,0.002509289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138411,"threshold_uncertainty_score":0.00715369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549479268278848,"score_gpt":0.2479944216914642,"score_spread":0.2324996290086758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}