{"id":"W2889803626","doi":"10.1038/s41598-018-31715-9","title":"Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Malaria Research and Control","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Alberta Innovates; Fundação de Amparo à Pesquisa do Estado de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Burroughs Wellcome Fund","keywords":"Plasmodium falciparum; Amodiaquine; Biology; Chloroquine; Artemisinin; Biochemistry; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001428139,0.0001913651,0.0001657449,0.0001819727,0.000115389,0.0003154706,0.0002296915,0.0003100753,0.0007460571],"category_scores_gemma":[0.0001676102,0.0001102944,0.0001241824,0.0001451366,0.0003240838,0.0001955956,0.0002302636,0.0002798831,0.0002815886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002756523,"about_ca_system_score_gemma":0.0001749848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166791,"about_ca_topic_score_gemma":0.0006934594,"domain_scores_codex":[0.9998935,0.00001607701,0.000008720098,0.0000260104,0.00003742002,0.00001825566],"domain_scores_gemma":[0.9997922,0.00002798815,0.0000758169,0.00001875634,0.00005053178,0.00003481707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062556,0.00001062102,0.0006258063,0.00002212788,0.000003481896,0.0000616241,0.000007759967,0.00002226337,0.9984092,0.000067269,0.00003218283,0.0006314022],"study_design_scores_gemma":[0.00004286341,0.0002346083,0.1178436,0.00001806749,0.0000364129,0.001198833,0.0001255343,0.002913992,0.8739926,0.0004736136,0.003102236,0.0000176905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914793,0.0031613,0.002906847,0.0004879391,0.0000206247,0.000007209495,0.0003105065,0.00005783362,0.001568565],"genre_scores_gemma":[0.9971089,0.00103842,0.0008751182,0.00008347029,0.00001170163,0.000005844281,0.0002735967,0.00001201878,0.0005909471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166791,"threshold_uncertainty_score":0.002495885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02759265679401319,"score_gpt":0.286550442163571,"score_spread":0.2589577853695578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}