{"id":"W2889887419","doi":"10.1200/jco.2019.37.15_suppl.tps4597","title":"PROSPER: A phase III randomized study comparing perioperative nivolumab (nivo) versus observation in patients with renal cell carcinoma (RCC) undergoing nephrectomy (ECOG-ACRIN 8143).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Calgary; McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Renal cell carcinoma; Nivolumab; Perioperative; Nephrectomy; Internal medicine; Kidney cancer; Stage (stratigraphy); Blockade; Oncology; Urology; Surgery; Cancer; Immunotherapy; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003650492,0.001913315,0.003041238,0.0003889533,0.0005988035,0.001190314,0.001122536,0.00190206,0.00981711],"category_scores_gemma":[0.003459829,0.0007079722,0.00352537,0.0005401442,0.00110225,0.001459943,0.0008178942,0.003606332,0.001378111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001074084,"about_ca_system_score_gemma":0.00213901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00178881,"about_ca_topic_score_gemma":0.005206302,"domain_scores_codex":[0.9987197,0.0008140051,0.00007450156,0.0001970666,0.0000805626,0.000114078],"domain_scores_gemma":[0.9987271,0.0003390413,0.000421052,0.0001107735,0.0001064028,0.0002954686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.975971,0.002896158,0.0008354499,0.002305696,0.002429738,0.00002522187,0.00004010337,0.0002366795,0.001036799,0.000188954,0.002510767,0.01152352],"study_design_scores_gemma":[0.9662169,0.02818023,0.001782501,0.0001456578,0.001274278,0.0000325634,0.00002947255,0.0002005107,0.0001511778,0.0002987079,0.001671026,0.00001696725],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8755615,0.03981761,0.003774292,0.004449275,0.004248334,0.04353774,0.01741255,0.000590427,0.0106082],"genre_scores_gemma":[0.9244919,0.01144947,0.007890775,0.005355357,0.001256763,0.03471387,0.006620653,0.0001105787,0.008110492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00981711,"threshold_uncertainty_score":0.03284156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09170392916847256,"score_gpt":0.3946634578688735,"score_spread":0.3029595287004009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}