{"id":"W2889901051","doi":"10.1021/acs.biochem.8b00731","title":"Studies with Guanidinium- and Amidinium-Based Inhibitors Suggest Minimal Stabilization of Allylic Carbocation Intermediates by Dehydrosqualene and Squalene Synthases","year":2018,"lang":"en","type":"article","venue":"Biochemistry","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Carbocation; Chemistry; Stereochemistry; Allylic rearrangement; Pyrophosphate; Moiety; Active site; Enzyme; Biochemistry; Photochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002617128,0.0003196458,0.0003609772,0.00008690693,0.0001281738,0.0002385958,0.0002830283,0.0002639591,0.000668543],"category_scores_gemma":[0.0002331254,0.0001350229,0.0001764648,0.0000933031,0.0002034762,0.0002091206,0.0001078607,0.0003701999,0.0001976517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003839954,"about_ca_system_score_gemma":0.0002200587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001519459,"about_ca_topic_score_gemma":0.00219843,"domain_scores_codex":[0.999819,0.00003653662,0.00001998335,0.00003322259,0.00006302183,0.00002821332],"domain_scores_gemma":[0.9998429,0.00004900133,0.00003918316,0.00001276812,0.00002305376,0.00003306269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126584,0.00002614046,0.0001082463,0.00002812958,0.00000567015,0.0000232253,0.00001514173,0.0001568505,0.9986701,0.0000818152,0.0000126538,0.0007593264],"study_design_scores_gemma":[0.00001433892,0.000375652,0.0004939234,0.000002344661,0.000007525373,0.00005892232,0.000006544883,0.000633042,0.9976355,0.00001278321,0.0007564878,0.000002911451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931898,0.001411375,0.003387876,0.00005770087,0.00001322896,0.00004430607,0.0001454764,0.00004593213,0.001704286],"genre_scores_gemma":[0.9951691,0.0005080826,0.003009442,0.00002360616,0.000004176043,0.0000178049,0.0002957157,0.00001339043,0.0009586692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001519459,"threshold_uncertainty_score":0.003021181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008072904634172633,"score_gpt":0.2404846855740558,"score_spread":0.2324117809398832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}