{"id":"W2889977344","doi":"10.1016/j.cell.2018.08.041","title":"Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1612,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Research Council; Benoziyo Endowment Fund for the Advancement of Science; Abisch-Frenkel-Stiftung; Conseil National de la Recherche Scientifique; Leona M. and Harry B. Helmsley Charitable Trust; Canadian Institute for Advanced Research; Israel Science Foundation; Crown Human Genome Center; Bill and Melinda Gates Foundation; Rising Tide Foundation; Minerva Foundation; European Foundation for the Study of Diabetes; Howard Hughes Medical Institute","keywords":"Biology; Probiotic; Microbiome; Colonisation resistance; Colonization; Transcriptome; Gut flora; Immunology; Microbiology; Gut microbiome; Bioinformatics; Bacteria; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002493388,0.0001971585,0.0005053375,0.0003108158,0.0001847789,0.0006913669,0.0001325284,0.0004296195,0.001943518],"category_scores_gemma":[0.0006573193,0.0001384879,0.0002151922,0.0003453149,0.0002513576,0.0002640157,0.0003594454,0.0006219219,0.0002647059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001364151,"about_ca_system_score_gemma":0.0001363875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001685235,"about_ca_topic_score_gemma":0.0002600406,"domain_scores_codex":[0.9997721,0.00006195246,0.0000172504,0.0000554829,0.00004210512,0.00005106501],"domain_scores_gemma":[0.9996316,0.0000610579,0.0001559394,0.00004860093,0.000031491,0.00007122683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003390369,0.0003379662,0.3367957,0.0000971829,0.0002147989,0.0009544811,0.0002002206,0.0002238021,0.6332474,0.0003217942,0.0003256428,0.02389079],"study_design_scores_gemma":[0.00002423898,0.001122818,0.9775878,0.00001663068,0.0001067487,0.002190388,0.0003416968,0.0005459253,0.01681439,0.0003277403,0.0009087936,0.0000127964],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989396,0.0004291669,0.0001883045,0.00006188069,0.000006340215,0.000002675542,0.00004146944,0.000007325098,0.0003231826],"genre_scores_gemma":[0.9992951,0.0001749869,0.0002017469,0.00005286766,0.00001175069,0.000003378705,0.0000752463,0.000006689542,0.0001781646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001943518,"threshold_uncertainty_score":0.006501734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006659416955033526,"score_gpt":0.2428396378489442,"score_spread":0.2361802208939106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}