{"id":"W2890000379","doi":"10.1200/jco.2018.36.15_suppl.4088","title":"Outcomes in patients (pts) who had received sorafenib (S) as the only prior systemic therapy in the phase 3 CELESTIAL trial of cabozantinib (C) versus placebo (P) in advanced hepatocellular carcinoma (HCC).","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Internal medicine; Sorafenib; Hepatocellular carcinoma; Cabozantinib; Systemic therapy; Gastroenterology; Progression-free survival; Placebo; Overall survival; Oncology; Cancer; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001261802,0.0004778115,0.001358144,0.0002652756,0.0003247109,0.0005966153,0.0002359992,0.000725428,0.001620169],"category_scores_gemma":[0.001276963,0.0002485185,0.00217943,0.000463022,0.0004233729,0.0004719554,0.0004366856,0.001232941,0.0001601984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006052779,"about_ca_system_score_gemma":0.000738809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007294571,"about_ca_topic_score_gemma":0.001058192,"domain_scores_codex":[0.9996182,0.0001637975,0.00003267205,0.00007649207,0.00003071325,0.00007813102],"domain_scores_gemma":[0.9991611,0.0002038195,0.0002810717,0.00003952133,0.00003773494,0.0002766317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7655284,0.002952881,0.1886406,0.0007887523,0.003797125,0.0007610366,0.0001686704,0.002562904,0.005013034,0.0002035343,0.002120933,0.02746205],"study_design_scores_gemma":[0.1788969,0.2479808,0.5508427,0.0002017388,0.006812785,0.001803593,0.0003604298,0.005106532,0.002892558,0.0009880567,0.004030223,0.00008379984],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976016,0.001190423,0.0001216229,0.00009958904,0.00004729326,0.0001055102,0.0004641727,0.000005743225,0.0003640442],"genre_scores_gemma":[0.9976532,0.0004840545,0.0001275402,0.0001747517,0.00008158486,0.0002024665,0.001026493,0.000002593187,0.0002472042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001620169,"threshold_uncertainty_score":0.006673098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1666077747773456,"score_gpt":0.4300913041073774,"score_spread":0.2634835293300318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}