{"id":"W2890007148","doi":"10.1084/jem.20180939","title":"Zebrafish blastomere screen identifies retinoic acid suppression of <i>MYB</i> in adenoid cystic carcinoma","year":2018,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Harvard Stem Cell Institute; Conquer Cancer Foundation; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Heart, Lung, and Blood Institute; Boston Children's Hospital; National Cancer Institute; National Institutes of Health; Foundation for the National Institutes of Health; American Cancer Society; Adenoid Cystic Carcinoma Research Foundation; Howard Hughes Medical Institute","keywords":"Adenoid cystic carcinoma; Zebrafish; Retinoic acid; MYB; Biology; Carcinoma; Cancer research; Genetics; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006124449,0.000147629,0.0002745606,0.00008772402,0.00006551321,0.000005567101,0.0004379834,0.0000934613,0.000128441],"category_scores_gemma":[0.0001895593,0.00008997328,0.00006356316,0.0001429737,0.0006279253,0.0000111871,0.0001295197,0.0001658465,0.000003123795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000247002,"about_ca_system_score_gemma":0.0000689331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003515217,"about_ca_topic_score_gemma":0.000006043921,"domain_scores_codex":[0.9986485,0.0001599569,0.0005423626,0.0001301441,0.0003371622,0.0001818882],"domain_scores_gemma":[0.9990722,0.0000349867,0.0003850856,0.0002677852,0.0001665208,0.000073414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007386261,0.0000628933,0.00141448,0.00002504463,0.00002486157,0.00001176967,0.001092215,0.000001962641,0.9923774,0.000006012382,0.004124974,0.0001197543],"study_design_scores_gemma":[0.001417152,0.002376404,0.001328738,0.0002636235,0.00003948098,0.0002730865,0.003466304,0.000009042532,0.9899883,0.00003992318,0.0007084779,0.00008946977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811194,0.01680854,0.000136661,0.0001869796,0.0003864034,0.00009611423,0.000002553624,0.000002187347,0.001261148],"genre_scores_gemma":[0.9984098,0.0002562024,0.00009723028,0.0001586514,0.0008750955,0.000001868999,0.000008048926,0.00001722219,0.0001758771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01729039,"threshold_uncertainty_score":0.3669004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009595580808880962,"score_gpt":0.2721039916995877,"score_spread":0.2625084108907067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}