{"id":"W2890007148","doi":"10.1084/jem.20180939","title":"Zebrafish blastomere screen identifies retinoic acid suppression of <i>MYB</i> in adenoid cystic carcinoma","year":2018,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Harvard Stem Cell Institute; Conquer Cancer Foundation; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Heart, Lung, and Blood Institute; Boston Children's Hospital; National Cancer Institute; National Institutes of Health; Foundation for the National Institutes of Health; American Cancer Society; Adenoid Cystic Carcinoma Research Foundation; Howard Hughes Medical Institute","keywords":"Adenoid cystic carcinoma; Zebrafish; Retinoic acid; MYB; Biology; Carcinoma; Cancer research; Genetics; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682281,0.0003759556,0.0003388,0.0006357136,0.0002845502,0.0002217603,0.0002808842,0.0004006774,0.002672],"category_scores_gemma":[0.0001342065,0.0002376792,0.0004081285,0.0002075828,0.000282585,0.0001106928,0.0002762366,0.0004597858,0.0006487033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004624373,"about_ca_system_score_gemma":0.0004105124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004149088,"about_ca_topic_score_gemma":0.007477257,"domain_scores_codex":[0.999821,0.00002082797,0.00001915558,0.0000380144,0.0000712762,0.00002974137],"domain_scores_gemma":[0.9998823,0.0000359283,0.00003512254,0.00001213305,0.00001211556,0.00002228644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001651696,0.000005670442,0.0001224994,0.000008317326,0.000002671438,0.00009384777,0.000005518028,0.0000400552,0.9992924,0.00006057315,0.0000259429,0.0003260105],"study_design_scores_gemma":[0.00002145919,0.000141014,0.005074719,0.000004681977,0.00003459895,0.0005830764,0.0000295562,0.0008212022,0.9906422,0.00003090022,0.002609037,0.000007461065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978443,0.001262762,0.0105538,0.0003102805,0.0000381908,0.000238905,0.002944456,0.0003831292,0.005825569],"genre_scores_gemma":[0.9829558,0.001237167,0.006386151,0.0001220898,0.000006853447,0.0001087643,0.002061204,0.0001230128,0.006998998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004149088,"threshold_uncertainty_score":0.00893867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009595580808880962,"score_gpt":0.2721039916995877,"score_spread":0.2625084108907067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}