{"id":"W2890030948","doi":"10.1200/jco.2016.34.15_suppl.e16118","title":"Baseline lactate dehydrogenase (LDH) and overall survival (OS) in metastatic renal cell carcinoma (mRCC) patients (pts) treated with everolimus (EVE) versus sunitinib (SUN): Predictive biomarker analysis from the RECORD-3 trial.","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Lactate dehydrogenase; Sunitinib; Internal medicine; Temsirolimus; Renal cell carcinoma; Everolimus; Progression-free survival; Proportional hazards model; Gastroenterology; Hazard ratio; Urology; Oncology; Discovery and development of mTOR inhibitors; Overall survival; PI3K/AKT/mTOR pathway; Confidence interval; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001387192,0.000281919,0.0007100634,0.0002488066,0.0001641524,0.0004676647,0.000296903,0.0003621185,0.001427883],"category_scores_gemma":[0.001745934,0.0001343021,0.0008933942,0.0004963966,0.0002861968,0.0003487371,0.0003139991,0.0006705613,0.0001795338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004149025,"about_ca_system_score_gemma":0.0002883776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004909594,"about_ca_topic_score_gemma":0.0008784487,"domain_scores_codex":[0.9995683,0.0001970707,0.00004345117,0.00008483289,0.00006935211,0.00003699506],"domain_scores_gemma":[0.9988325,0.0003393461,0.0005228668,0.00005672924,0.00003972819,0.0002087515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2712071,0.001437651,0.6770835,0.0005088153,0.002437701,0.0001021355,0.0001003876,0.001645401,0.002580059,0.00008101833,0.001572651,0.04124361],"study_design_scores_gemma":[0.01732152,0.04332061,0.9299684,0.00007866477,0.002768885,0.000473822,0.00009816373,0.002518458,0.001602638,0.0002977349,0.001514481,0.0000366431],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978764,0.001076612,0.00006586766,0.00006905945,0.000009139189,0.00002999175,0.0006374539,0.000005382345,0.000230207],"genre_scores_gemma":[0.9986222,0.0002494909,0.00008944302,0.0000375592,0.00001880308,0.00003015613,0.0008420623,0.000001268271,0.0001089965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001427883,"threshold_uncertainty_score":0.007336259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1092548767671688,"score_gpt":0.3735871567249925,"score_spread":0.2643322799578237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}