{"id":"W2890089103","doi":"10.1200/jco.2018.36.15_suppl.8568","title":"Association between progression-free survival (PFS) rate (PFSR) and overall survival (OS) in LUME-Meso, a study of nintedanib (N) vs. placebo (P) in combination with first-line pemetrexed/cisplatin (PEM/CIS) in patients (pts) with malignant pleural mesothelioma (MPM).","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Hazard ratio; Placebo; Clinical endpoint; Confidence interval; Progression-free survival; Gastroenterology; Surgery; Randomized controlled trial; Overall survival; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002913903,0.0007130182,0.001529075,0.0003449438,0.0002216589,0.0005765195,0.0005617844,0.000833755,0.002190445],"category_scores_gemma":[0.002451062,0.0004599557,0.001382514,0.0002829085,0.0006718494,0.0006136684,0.0003914305,0.002005147,0.0002618501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004188626,"about_ca_system_score_gemma":0.0005558724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003138611,"about_ca_topic_score_gemma":0.0007086495,"domain_scores_codex":[0.9991612,0.000591518,0.00003604895,0.0001011107,0.00005059707,0.00005945219],"domain_scores_gemma":[0.9982219,0.0007861909,0.0004472297,0.0001076759,0.00005501654,0.0003819691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9582593,0.005362999,0.006167096,0.0004986237,0.001000353,0.00003612177,0.00005939693,0.0006215918,0.005707119,0.00004948763,0.0003621392,0.02187579],"study_design_scores_gemma":[0.3724904,0.5687478,0.05062629,0.00006763063,0.002322262,0.0001468809,0.00003847422,0.001933826,0.002240747,0.0001543399,0.001193333,0.00003811769],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944814,0.004004012,0.0002682049,0.0001957793,0.00007089264,0.0001900264,0.0002558467,0.00002487946,0.0005088826],"genre_scores_gemma":[0.9975117,0.0008820476,0.0003806737,0.0001577282,0.0001296581,0.0002049188,0.0003218177,0.000006264348,0.0004051446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002913903,"threshold_uncertainty_score":0.01541042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04363397691707189,"score_gpt":0.3791385237850813,"score_spread":0.3355045468680095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}