{"id":"W2890108083","doi":"10.1073/pnas.1811866115","title":"Interleukin-22 promotes phagolysosomal fusion to induce protection against <i>Salmonella enterica</i> Typhimurium in human epithelial cells","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Killam Trusts; Crohn's and Colitis Foundation; Wellcome Trust; Universität Basel; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Leona M. and Harry B. Helmsley Charitable Trust; Crohn's and Colitis Foundation of America","keywords":"Salmonella enterica; Microbiology; Biology; Salmonella; Immune system; Intestinal epithelium; Transcriptome; Enterobacteriaceae; Antimicrobial; Phenotype; Epithelium; Gene; Bacteria; Immunology; Gene expression; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001907535,0.0001838026,0.0001614962,0.0001087133,0.00008935751,0.0003037378,0.00005948126,0.0001445618,0.001309027],"category_scores_gemma":[0.00008962556,0.00008865027,0.0002479288,0.00007004816,0.0001314167,0.00009058377,0.0001834496,0.0003158941,0.0003360198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001567468,"about_ca_system_score_gemma":0.000188091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004492229,"about_ca_topic_score_gemma":0.0007433295,"domain_scores_codex":[0.9998755,0.00003233292,0.00001248496,0.00002109822,0.0000248269,0.00003373236],"domain_scores_gemma":[0.9999156,0.00001430633,0.00001728603,0.00001433076,0.00001372471,0.00002473591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005673996,0.00001514621,0.0002237342,0.00001755975,0.000002717468,0.00003961647,0.00001401274,0.0000200667,0.9989755,0.00002464492,0.00003002576,0.000580193],"study_design_scores_gemma":[0.00001464109,0.0004038229,0.008577436,0.000006608174,0.00001330921,0.0003300706,0.00006598751,0.0004625757,0.9880482,0.00002515725,0.002049477,0.000002709722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955136,0.001050455,0.001742931,0.0001084444,0.00002618558,0.00002572119,0.0002558435,0.00004606384,0.001230727],"genre_scores_gemma":[0.9972048,0.0003460532,0.0009243579,0.00005659798,0.000005473381,0.00001339928,0.0003184731,0.000008641136,0.001122036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309027,"threshold_uncertainty_score":0.004379153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05520351774424084,"score_gpt":0.3460802543568352,"score_spread":0.2908767366125944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}