{"id":"W2890129786","doi":"10.1200/jco.2016.34.15_suppl.9509","title":"Mikie: A randomized, double-blinded, regimen-controlled, phase 2 study to assess the efficacy and safety of two different vismodegib (VISMO) regimens in patients (pts) with multiple basal cell carcinomas (BCCs).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Regimen; Vismodegib; Adverse effect; Internal medicine; Population; Placebo; Basal cell carcinoma; Surgery; Gastroenterology; Basal cell; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005416424,0.0003165382,0.002541567,0.0001346006,0.0000760981,0.00001378074,0.0004025417,0.0002126875,0.000007259999],"category_scores_gemma":[0.00289743,0.0001437218,0.0003907187,0.0001128708,0.0004362426,0.00001185123,0.0002633618,0.0004244564,0.000001453428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006522888,"about_ca_system_score_gemma":0.0004268778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003190114,"about_ca_topic_score_gemma":0.0001900289,"domain_scores_codex":[0.994038,0.002076582,0.002646608,0.0004494322,0.000429105,0.0003602094],"domain_scores_gemma":[0.9923864,0.004413336,0.001919813,0.00043595,0.0005814568,0.0002630489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7954476,0.009508218,0.1844944,0.0000126608,0.0009174003,0.0000511271,0.000430885,0.0000695797,0.00397578,0.00001598259,0.0002316814,0.004844699],"study_design_scores_gemma":[0.9051629,0.02508198,0.06484722,0.00008507783,0.0004512405,0.000008269853,0.0002718339,0.00002549895,0.003023755,0.00001997184,0.0008088799,0.0002134165],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944079,0.0002988118,0.00138043,0.001185475,0.0003963654,0.002137539,0.0000104186,0.000003193206,0.0001798465],"genre_scores_gemma":[0.9985245,0.0001790285,0.0004139027,0.0003381273,0.0003343997,0.00005341287,0.00000203693,0.00002914256,0.0001254578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1196472,"threshold_uncertainty_score":0.5860805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07855143791029871,"score_gpt":0.4039875667882645,"score_spread":0.3254361288779657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}