{"id":"W2890129786","doi":"10.1200/jco.2016.34.15_suppl.9509","title":"Mikie: A randomized, double-blinded, regimen-controlled, phase 2 study to assess the efficacy and safety of two different vismodegib (VISMO) regimens in patients (pts) with multiple basal cell carcinomas (BCCs).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Regimen; Vismodegib; Adverse effect; Internal medicine; Population; Placebo; Basal cell carcinoma; Surgery; Gastroenterology; Basal cell; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00151796,0.001292087,0.00194947,0.0004207069,0.0004414042,0.0008430475,0.0008469538,0.001483906,0.009061286],"category_scores_gemma":[0.001530704,0.0007070744,0.001016898,0.0003238864,0.000724352,0.00103804,0.0004398683,0.00270688,0.001134081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00084497,"about_ca_system_score_gemma":0.001525566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006162949,"about_ca_topic_score_gemma":0.002561471,"domain_scores_codex":[0.9994051,0.0002760588,0.0000353602,0.0001379222,0.00006266517,0.00008287192],"domain_scores_gemma":[0.99936,0.0001393256,0.0001815202,0.00004344995,0.00004499985,0.0002306082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9453906,0.02520331,0.001022777,0.0006271524,0.0007742116,0.00003158409,0.00006020832,0.0003095284,0.005613093,0.0001349484,0.001318644,0.0195139],"study_design_scores_gemma":[0.9043274,0.09172448,0.002028469,0.00002544882,0.0002912191,0.00003253973,0.00001598975,0.0002448572,0.0003669876,0.00007971874,0.0008505668,0.0000123703],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725697,0.003143023,0.001245571,0.0007073094,0.0004065139,0.01451651,0.002885335,0.0001975063,0.004328633],"genre_scores_gemma":[0.9606963,0.002062705,0.004335678,0.0022153,0.0003557036,0.02174014,0.002214675,0.00004739147,0.006332177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009061286,"threshold_uncertainty_score":0.03031301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07855143791029871,"score_gpt":0.4039875667882645,"score_spread":0.3254361288779657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}