{"id":"W2890130812","doi":"10.1016/j.bioorg.2018.09.004","title":"Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes","year":2018,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Narodowe Centrum Nauki","keywords":"Chemistry; Colchicine; Tubulin; Vinblastine; Docking (animal); In vitro; Paclitaxel; Microtubule; Combretastatin; Stereochemistry; Cisplatin; Cytotoxicity; Doxorubicin; Biochemistry; Cancer; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001528662,0.0002184135,0.0003590162,0.00001118417,0.00008678383,0.00002024406,0.0001876084,0.0002606672,0.00167999],"category_scores_gemma":[0.0005404867,0.0001683614,0.00007460611,0.0001082957,0.0003642773,0.00005075756,0.0001513676,0.0001667795,0.000005585144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002919973,"about_ca_system_score_gemma":0.00003886781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002755503,"about_ca_topic_score_gemma":0.000001987209,"domain_scores_codex":[0.9989784,0.00002314022,0.0001919211,0.0004088688,0.0001673033,0.0002303784],"domain_scores_gemma":[0.9990977,0.0002321313,0.0001741139,0.0003195701,0.00008765359,0.00008883244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007578211,0.000121754,0.004091761,0.0001828904,0.000059381,0.000005166249,0.00003874222,3.33427e-8,0.9910358,0.00001633396,0.00002585897,0.004346477],"study_design_scores_gemma":[0.0001822125,0.00002160571,0.002086187,0.0001012596,0.00004088156,0.00002574278,0.00007009768,0.00004765379,0.9967958,0.0001008853,0.0003211646,0.0002065144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881919,0.0002160647,0.00002094795,0.0001734141,0.00001543423,0.00004849373,0.00002419097,0.00006286764,0.01124667],"genre_scores_gemma":[0.9994975,0.00004388435,0.00007586139,0.00003121683,0.0002478237,0.00001051277,0.000002539893,0.00001704767,0.00007360828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01130559,"threshold_uncertainty_score":0.9992326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328098497447399,"score_gpt":0.2345739880228907,"score_spread":0.2212930030484167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}