{"id":"W2890229739","doi":"10.1164/rccm.201803-0461oc","title":"Anti–IL-5 in Mild Asthma Alters Rhinovirus-induced Macrophage, B-Cell, and Neutrophil Responses (MATERIAL). A Placebo-controlled, Double-Blind Study","year":2018,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"GlaxoSmithKline","keywords":"Mepolizumab; Immunology; Medicine; Eosinophil cationic protein; Exhaled nitric oxide; Eosinophil; Asthma; Sputum; Immune system; Pathology; Spirometry; Tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002255702,0.001466859,0.002711789,0.000527103,0.0006045604,0.0006296929,0.0009987521,0.001771869,0.004383889],"category_scores_gemma":[0.0009374142,0.0007650827,0.00143795,0.0002891308,0.001501144,0.0007289575,0.000382185,0.002288076,0.0006627287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003737039,"about_ca_system_score_gemma":0.0008619632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005979711,"about_ca_topic_score_gemma":0.001223083,"domain_scores_codex":[0.9990415,0.0004202949,0.0001153652,0.0001449344,0.00009397,0.0001838452],"domain_scores_gemma":[0.9990001,0.0001798888,0.0002044963,0.0001320933,0.00008629676,0.0003970734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8747405,0.02629947,0.0006909448,0.001042752,0.0005301264,0.00006924961,0.00006186833,0.000141317,0.07705448,0.00008394432,0.000395724,0.01888962],"study_design_scores_gemma":[0.4665793,0.5113233,0.008534583,0.0000548486,0.0005656845,0.00008400777,0.00003470218,0.0003090032,0.01127089,0.00009386744,0.001122777,0.00002711083],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895152,0.005131297,0.0007940758,0.0002038832,0.0005424735,0.002532023,0.0005328496,0.0001202365,0.0006280554],"genre_scores_gemma":[0.9878545,0.002421692,0.001657615,0.0005473656,0.0007943407,0.002948918,0.0007130039,0.00002241429,0.003040156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004383889,"threshold_uncertainty_score":0.0146656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0285343889781873,"score_gpt":0.3419288145925864,"score_spread":0.3133944256143991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}