{"id":"W2890293509","doi":"10.1158/1535-7163.mct-18-0348","title":"Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Canadian Centre for Applied Research in Cancer Control; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"SMARCA4; Biology; EZH2; Cancer research; Histone deacetylase; Histone Acetyltransferases; Acetylation; Histone; Epigenetics; Chromatin remodeling; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008593671,0.0002105443,0.0002782967,0.0002561754,0.00009696633,0.0001604318,0.000161909,0.000130628,0.001210536],"category_scores_gemma":[0.00006913021,0.00007764006,0.000194287,0.0001783199,0.0001150714,0.0001275336,0.00009443352,0.000363758,0.0001214079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095554,"about_ca_system_score_gemma":0.0002343098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005663111,"about_ca_topic_score_gemma":0.002153503,"domain_scores_codex":[0.9999548,0.000005635427,0.000004237805,0.000007200243,0.00001082564,0.0000171757],"domain_scores_gemma":[0.9999734,0.000005006145,0.00000517749,0.00000345111,0.000003317251,0.000009714017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001332519,0.0006838223,0.0007897714,0.000147168,0.00004889964,0.0001171138,0.00002577383,0.0003596967,0.9742188,0.0002644983,0.0004740531,0.02153777],"study_design_scores_gemma":[0.0008929162,0.01051919,0.01630811,0.00001258694,0.0001199616,0.0006763488,0.00005326103,0.001905069,0.958409,0.0001085226,0.01098539,0.000009697205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993699,0.003160416,0.0006488845,0.00009749195,0.00005641734,0.00008680025,0.000200054,0.00007639069,0.001974618],"genre_scores_gemma":[0.9971384,0.001133925,0.0004099276,0.00003837907,0.00001151087,0.00003641198,0.0002434094,0.000005596551,0.0009824483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001210536,"threshold_uncertainty_score":0.004049659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518160534608104,"score_gpt":0.2597628155302856,"score_spread":0.2445812101842046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}