{"id":"W2890293509","doi":"10.1158/1535-7163.mct-18-0348","title":"Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Canadian Centre for Applied Research in Cancer Control; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"SMARCA4; Biology; EZH2; Cancer research; Histone deacetylase; Histone Acetyltransferases; Acetylation; Histone; Epigenetics; Chromatin remodeling; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001330608,0.0002364635,0.0002754973,0.00007159515,0.00004783764,0.000007665804,0.0003022868,0.000144871,0.000006847785],"category_scores_gemma":[0.00001209676,0.0001843815,0.0001114795,0.0004266221,0.0002468332,0.000004160919,0.0001384987,0.0001438206,0.000001677968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001066532,"about_ca_system_score_gemma":0.000436645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000935881,"about_ca_topic_score_gemma":0.0007922979,"domain_scores_codex":[0.9987398,0.00007710338,0.0002966379,0.0003884117,0.0002116456,0.0002864399],"domain_scores_gemma":[0.9988679,0.000008878757,0.0001843671,0.0006480152,0.0002216068,0.00006925925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003818885,0.0001281717,0.005427958,0.00008548877,0.00004421733,0.000004202991,0.0002612952,0.0009570679,0.9906432,0.000004719623,0.00007542562,0.001986367],"study_design_scores_gemma":[0.000826135,0.0005913311,0.002588856,0.0001200303,0.0000788042,0.000007330335,0.00005403942,0.0002613482,0.9944691,0.000009263915,0.0007579821,0.0002357703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996412,0.002133831,0.0004701208,0.0001370687,0.0002565359,0.0003330327,0.00002278076,0.000007201141,0.0002274249],"genre_scores_gemma":[0.9988377,0.00007978294,0.0003656941,0.000387081,0.0001091253,0.00002137981,0.000006900941,0.00005236985,0.0001399417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003825912,"threshold_uncertainty_score":0.7518859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518160534608104,"score_gpt":0.2597628155302856,"score_spread":0.2445812101842046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}