{"id":"W2890319629","doi":"10.1200/jco.2017.35.15_suppl.5014","title":"Post hoc analysis of a phase III study to test the association between circulating <i>methylated glutathione s transferase (mGSTP1</i>) DNA levels and response to docetaxel (DTX) in metastatic castration resistant prostate cancer (mCRPC).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; GSTP1; Docetaxel; Internal medicine; Prostate cancer; Post-hoc analysis; Oncology; Cancer; Gastroenterology; Glutathione; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003837883,0.0009686831,0.001439744,0.0002234134,0.0002618248,0.0005739724,0.0004834671,0.000637621,0.00382535],"category_scores_gemma":[0.002063554,0.0002998106,0.001437771,0.0002582875,0.0006926711,0.0003651456,0.00032962,0.00155601,0.0004080046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000667658,"about_ca_system_score_gemma":0.001497448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004747076,"about_ca_topic_score_gemma":0.0009775008,"domain_scores_codex":[0.9988226,0.0005950563,0.00006646653,0.0002125653,0.0001057622,0.0001975178],"domain_scores_gemma":[0.9967012,0.001148508,0.0006365076,0.0004713129,0.0001834307,0.0008590186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9110917,0.02048046,0.02421043,0.0001562998,0.001666532,0.0001139641,0.0001024977,0.0009449377,0.02695382,0.00009369589,0.001096798,0.01308887],"study_design_scores_gemma":[0.08551861,0.837686,0.05895491,0.00001039854,0.001341286,0.0001308703,0.00004398951,0.002096051,0.01251068,0.0001245864,0.001562113,0.0000203659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969513,0.000184251,0.0005672817,0.000077444,0.00006073428,0.0008914659,0.0006780482,0.00003180679,0.0005575628],"genre_scores_gemma":[0.9925735,0.00009827034,0.00164972,0.0002201362,0.00009280733,0.001619767,0.001739662,0.00002348968,0.001982673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003837883,"threshold_uncertainty_score":0.02029693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09317301733335843,"score_gpt":0.4697151546354394,"score_spread":0.376542137302081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}